Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1021627 | 0.88 | L3MBTL1 (0.41) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL1021384 | 0.81 | CA2 (0.48) | ALDH1A1POLBCYP2C9MAPK1CYP2C19 | |
| SCHEMBL1021779 | 0.78 | ALOX15 (0.42) | ALDH1A1MAPTHPGDPOLBMAPK1 | |
| SCHEMBL929959 | 0.76 | RAB9A (0.46) | ALDH1A1MEN1KMT2AMAPK1RAB9A | |
| SCHEMBL30883901 | 0.76 | RAB9A (0.46) | ALDH1A1MEN1KMT2AMAPK1RAB9A | |
| SCHEMBL2424549 | 0.75 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL155088 | 0.75 | AHR (0.46) | ALDH1A1HSD17B10TP53 | |
| SCHEMBL28996996 | 0.73 | ACHE (0.35) | ALDH1A1MAPTACHE | |
| SCHEMBL858370 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL30424732 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187462-B2 | Substituted quinazolines as serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2739618-B1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20150087664-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2015-03-26 | — | — | US | disclosed |
| EP-2739618-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013020062-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-02-07 | — | — | WO | disclosed |
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | disclosed |
| US-20070225349-A1 | Substituted 4-(Indazol-3-yl)phenols | WYETH (US) | 2007-09-27 | — | — | US | disclosed |
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1542976-A1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | Wyeth (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1493741-A2 | Benzo[b]thiophene compounds, intermediates, processes, compositions and methods | Eli Lilly & Company (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0826683-B1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20040167127-A1 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2004-08-26 | — | — | US | disclosed |
| WO-2004031159-A1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH (US) | 2004-04-15 | — | — | WO | disclosed |
| US-5998442-A | ANTICHOLESTEROL AGENTS | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0826683-A1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225349-A1 | Substituted 4-(Indazol-3-yl)phenols | INSR, TNNI3, INSRR | ALDH1A1 2279/4885MEN1 1719/4885KMT2A 2656/4885 |
| US-20040167127-A1 | Substituted 4-(indazol-3-yl)phenols | INSR, MSR1, TNNI3 | ALDH1A1 1965/4885MEN1 2749/4885KMT2A 2418/4885 |
| US-20150087664-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | MAP3K1, MAP3K3, MAP3K2 | ALDH1A1 2948/4885MEN1 1450/4885KMT2A 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.