Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.40 |
| ▸ | MMP1 | P03956 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038954 | 0.91 | MMP3 (0.43) | ADAM17MMP1MMP3MMP9MAPT | |
| SCHEMBL4035748 | 0.82 | MMP1 (0.40) | ADAMTS4ADAM17MMP1MMP3MMP9 | |
| SCHEMBL4038496 | 0.76 | PSEN1 (0.39) | MMP1MMP3MMP9ALDH1A1KMT2A | |
| SCHEMBL4035688 | 0.72 | CA12 (0.39) | MMP9 | |
| SCHEMBL4038524 | 0.69 | MMP2 (0.34) | MMP1MMP3MMP9 | |
| SCHEMBL28211954 | 0.64 | KMT2A (0.62) | EGFRMAPTALDH1A1MCHR1KMT2A | |
| SCHEMBL1956688 | 0.61 | LTA4H (0.79) | EGFRMCHR1KMT2ARAB9AHTT | |
| SCHEMBL12041572 | 0.61 | RAB9A (0.71) | EGFRMAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL22411529 | 0.61 | RAB9A (0.53) | MAPTALDH1A1RAB9AHTT | |
| Lithium Ion SCHEMBL9984158 | 0.61 | MAPT (0.67) | EGFRMAPTALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | disclosed |