Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927380 | 0.91 | CYP2D6 (0.45) | KMT2AMEN1GAAHTTSMN1; SMN2 | |
| SCHEMBL4034055 | 0.88 | L3MBTL1 (0.45) | KMT2AMEN1GAAHTTTSHR | |
| SCHEMBL4035567 | 0.88 | LMNA (0.48) | KMT2AMEN1GAAHTTTSHR | |
| SCHEMBL3925883 | 0.84 | CXCR3 (0.39) | KMT2AMEN1GAAHTTSMN1; SMN2 | |
| SCHEMBL3916725 | 0.84 | KMT2A (0.40) | KMT2AMEN1GAAHTTSMN1; SMN2 | |
| SCHEMBL4032408 | 0.84 | ALDH1A1 (0.52) | KMT2AMEN1GAAHTTSMN1; SMN2 | |
| SCHEMBL4041475 | 0.83 | MMP2 (0.39) | KMT2AMEN1GAAHTTSMN1; SMN2 | |
| SCHEMBL4037038 | 0.83 | SMN1; SMN2 (0.41) | KMT2AGAAHTTSMN1; SMN2MAPT | |
| SCHEMBL4041453 | 0.82 | MEN1 (0.42) | KMT2AMEN1GAAHTTSMN1; SMN2 | |
| SCHEMBL3915453 | 0.82 | HSD11B1 (0.48) | KMT2AMEN1GAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |