Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035567 | 0.90 | LMNA (0.48) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL4041277 | 0.88 | KMT2A (0.41) | TSHRALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3927380 | 0.88 | CYP2D6 (0.45) | L3MBTL1TSHRMAPK1ALDH1A1KMT2A | |
| SCHEMBL3919279 | 0.85 | L3MBTL1 (0.44) | L3MBTL1TSHRMAPK1RECQLMMP1 | |
| SCHEMBL4037038 | 0.83 | SMN1; SMN2 (0.41) | KMT2AMAPTPKMGAAHTT | |
| SCHEMBL4041475 | 0.82 | MMP2 (0.39) | L3MBTL1TSHRMMP13ALDH1A1KMT2A | |
| SCHEMBL4032408 | 0.81 | ALDH1A1 (0.52) | TSHRRECQLALDH1A1KMT2AMEN1 | |
| SCHEMBL3920468 | 0.81 | HSD11B1 (0.46) | TSHRALDH1A1KMT2AMEN1GAA | |
| SCHEMBL4037894 | 0.81 | ALDH1A1 (0.54) | L3MBTL1TSHRMAPK1ALDH1A1KMT2A | |
| SCHEMBL5666160 | 0.80 | TSHR (0.49) | L3MBTL1TSHRMAPK1RECQLMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |