SCHEMBL40374

SCHEMBL40374

O=C(Cl)c1cccc(I)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
TSHR P16473 1/20 0.50
HDAC1 Q13547 1/20 0.44
HDAC2 Q92769 1/20 0.44
GRM5 P41594 1/20 0.44
F2 P00734 1/20 0.42
MTOR P42345 3/20 0.41
TP53BP1 Q12888 1/20 0.41
MGLL Q99685 1/20 0.41
KAT6A Q92794 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
SIGMAR1 Q99720 1/20 0.39
MYC P01106 1/20 0.38
MAX P61244 1/20 0.38
ATM Q13315 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PARP1 P09874 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29439753 1.00 ALDH1A1 (0.50) ALDH1A1TSHRHDAC1HDAC2GRM5
Methylene Chloride SCHEMBL28878447 0.94 ALDH1A1 (0.46) ALDH1A1TSHRHDAC1HDAC2GRM5
SCHEMBL27510 0.83 ALDH1A1 (0.59) ALDH1A1TSHRATMTDP1L3MBTL1
SCHEMBL30967896 0.83 MGLL (0.42) HDAC1HDAC2GRM5F2MTOR
SCHEMBL3673834 0.81 ATM (0.58) ALDH1A1HDAC1HDAC2GRM5F2
SCHEMBL18079795 0.81 CES2 (0.54) HDAC1HDAC2GRM5F2MTOR
Bromide SCHEMBL31026552 0.80 ALDH1A1 (0.57) ALDH1A1TSHRATMTDP1L3MBTL1
Iodide SCHEMBL29916276 0.80 ALDH1A1 (0.57) ALDH1A1TSHRATMTDP1L3MBTL1
Hydrochloric Acid SCHEMBL8084573 0.80 ALDH1A1 (0.57) ALDH1A1TSHRATMTDP1L3MBTL1
Benzene SCHEMBL9243917 0.80 ALDH1A1 (0.57) ALDH1A1TSHRATMTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 313 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115708891-B Developing drug-carrying microsphere based on microfluidic technology and preparation method and application thereof 四川大学 2024-06-18 CN claimed
CN-110483503-B Imidazole carbene ligand with amide remote basic functional group and synthesis method and application thereof 浙江工业大学 2020-11-13 CN claimed
CN-110483503-A Imidazoles carbenes and its synthetic method and application with the long-range basic functionality of amide UNIV ZHEJIANG TECHNOLOGY 2019-11-22 CN claimed
US-4328162-A Process for preparing 9,11-unsaturated steroidal compound from the corresponding saturated steroidal compound EASTMAN KODAK COMPANY (US) 1982-05-04 US claimed
US-4323512-A Process for the preparation of steroidal 17α-arylcarboxylates SCHERING CORPORATION (US) 1982-04-06 US claimed
US-4252719-A REMOVAL OF A TERTIARY HYDROGEN FROM A 5-A-STEROID BY CHLORINATING THE STEROID BEING FIRST ESTERIFIED BY AN IODOARYL-CONTAINING ESTERIFICATION AGENT RESEARCH CORPORATION (US) 1981-02-24 US claimed
US-12617789-B2 Small molecular inhibitors of NF-κb inducing kinase JANSSEN PHARMACEUTICA NV (BE) 2026-05-05 US disclosed
US-20260116910-A1 POLYCYCLIC COMPOUNDS AND METHODS THEREOF HEPAITECH BEIJING BIOPHARMA TECH CO LTD (CN) 2026-04-30 US disclosed
US-20260021192-A1 PROTEINS HAVING A COVALENT WARHEAD TOPAZ THERAPEUTICS INC (US) 2026-01-22 US disclosed
US-20250282785-A1 PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE JANSSEN PHARMACEUTICA NV (BE) 2025-09-11 US disclosed
EP-4554941-A1 HERBICIDAL BENZOXAZINES FMC Corporation (US) 2025-05-21 EP disclosed
US-12281060-B2 Remodilins for airway remodeling and organ fibrosis THE UNIVERSITY OF CHICAGO (US) 2025-04-22 US disclosed
CN-119707930-A Aromatic ring compound and its prepn and use 甘李药业股份有限公司 2025-03-28 CN disclosed
US-4335055-A Process for the preparation of alkenylbenzene derivatives or alkenylnaphthalene derivatives CIBA-GEIGY CORPORATION (US) 1982-06-15 US disclosed
US-4328162-A Process for preparing 9,11-unsaturated steroidal compound from the corresponding saturated steroidal compound EASTMAN KODAK COMPANY (US) 1982-05-04 US disclosed
US-4323512-A Process for the preparation of steroidal 17α-arylcarboxylates SCHERING CORPORATION (US) 1982-04-06 US disclosed
US-4260464-A Process for the preparation of 17α-(3-iodobenzoyloxy)-9α-chloro-4-pregnene-3,20-diones and their D-homo homologs SCHERING AKTIENGESELLSCHAFT (DE) 1981-04-07 US disclosed
US-4252719-A REMOVAL OF A TERTIARY HYDROGEN FROM A 5-A-STEROID BY CHLORINATING THE STEROID BEING FIRST ESTERIFIED BY AN IODOARYL-CONTAINING ESTERIFICATION AGENT RESEARCH CORPORATION (US) 1981-02-24 US disclosed
US-4252729-A Steroids and process for their manufacture HOFFMANN-LA ROCHE INC. (US) 1981-02-24 US disclosed
US-4197406-A HORMONES HOFFMANN-LA ROCHE INC. (US) 1980-04-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250282785-A1 PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE NFKBIA, IKBKG, IKBKB ALDH1A1 4167/4885TSHR 4220/4885HDAC1 993/4885
US-12617789-B2 Small molecular inhibitors of NF-κb inducing kinase IRAK3, IKBKB, IKBKG ALDH1A1 3824/4885TSHR 3881/4885HDAC1 436/4885
US-20260116910-A1 POLYCYCLIC COMPOUNDS AND METHODS THEREOF NR1H3, NR1H2, CPT1A ALDH1A1 598/4885TSHR 495/4885HDAC1 186/4885
US-12281060-B2 Remodilins for airway remodeling and organ fibrosis MYLK, MFAP1, FIBP ALDH1A1 3220/4885TSHR 3401/4885HDAC1 1433/4885
US-20260021192-A1 PROTEINS HAVING A COVALENT WARHEAD RIOX2, ORC3, DCLRE1A ALDH1A1 3714/4885TSHR 2255/4885HDAC1 1786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.