Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037611 | 0.85 | ALDH1A1 (0.53) | LMNAMAPK1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL3927380 | 0.85 | CYP2D6 (0.45) | LMNAMAPK1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL3919257 | 0.83 | LMNA (0.51) | LMNATDP1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4041414 | 0.82 | KMT2A (0.46) | LMNAMAPK1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4041475 | 0.81 | MMP2 (0.39) | LMNASMN1; SMN2ALDH1A1GAAHTT | |
| SCHEMBL4041453 | 0.81 | MEN1 (0.42) | LMNASMN1; SMN2ALDH1A1GAAHTT | |
| SCHEMBL4042839 | 0.79 | KMT2A (0.46) | LMNASMN1; SMN2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL4038204 | 0.79 | EPHX2 (0.47) | MAPK1ALDH1A1L3MBTL1CYP2D6KMT2A | |
| SCHEMBL5668669 | 0.79 | LMNA (0.59) | LMNATDP1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4035567 | 0.79 | LMNA (0.48) | LMNAALDH1A1GAAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |