Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 9/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 9/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | MC1R | Q01726 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042529 | 0.94 | BCL2 (0.38) | ITGA4ITGB7CTSKBCL2ELANE | |
| SCHEMBL4043465 | 0.93 | MC4R (0.41) | ITGA4ITGB7CTSKBCL2ELANE | |
| SCHEMBL4045571 | 0.90 | CTSK (0.46) | CTSKELANE | |
| SCHEMBL4045597 | 0.90 | ACE (0.36) | CTSKBCL2F2ELANEMC4R | |
| SCHEMBL4043596 | 0.89 | ELANE (0.38) | CTSKELANEMC4RMC3RMC1R | |
| SCHEMBL4045511 | 0.89 | F2 (0.38) | ITGA4ITGB7CTSKF2ITGB3 | |
| SCHEMBL4045924 | 0.88 | USP30 (0.40) | USP30ITGA4ITGB7ITGB3ITGAV | |
| SCHEMBL4041797 | 0.86 | CTSK (0.50) | USP30CTSKF2MC4RMC3R | |
| SCHEMBL6213140 | 0.85 | CTSK (0.44) | CTSKBCL2ITGB3MC4RMC3R | |
| SCHEMBL4046868 | 0.84 | ITGB1 (0.37) | ITGA4ITGB7CTSKBCL2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |