Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | HTRA1 | Q92743 | 6/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 4/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | MC1R | Q01726 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044814 | 0.94 | FNTA (0.35) | USP30ITGA4ITGB7MC4RMC3R | |
| SCHEMBL4040539 | 0.93 | MC4R (0.41) | USP30HTRA1ITGA4ITGB7MC4R | |
| SCHEMBL6210306 | 0.93 | CTSK (0.43) | USP30HTRA1ITGA4ITGB7MC4R | |
| SCHEMBL4045521 | 0.90 | CTSK (0.43) | — | |
| SCHEMBL4043350 | 0.89 | HTRA1 (0.35) | HTRA1ITGA4ITGB7HDAC8MC4R | |
| SCHEMBL4052303 | 0.89 | CTSK (0.35) | MC4RMC3RMC1R | |
| SCHEMBL4041556 | 0.88 | CTSK (0.43) | USP30HTRA1ITGA4ITGB7ITGB3 | |
| SCHEMBL4042585 | 0.88 | USP30 (0.39) | USP30ITGA4ITGB7ITGB3ITGAV | |
| SCHEMBL4051785 | 0.88 | ITGA4 (0.39) | USP30HTRA1ITGA4ITGB7ITGB3 | |
| SCHEMBL4041845 | 0.86 | CTSK (0.50) | USP30HTRA1MC4RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |