Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | MC1R | Q01726 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.34 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042585 | 0.94 | USP30 (0.39) | BCL2CTSKELANEMC4RMC3R | |
| SCHEMBL4043465 | 0.94 | MC4R (0.41) | BCL2CTSKACEELANEGPR132 | |
| SCHEMBL4045597 | 0.93 | ACE (0.36) | BCL2CTSKACEELANEGPR132 | |
| SCHEMBL6213140 | 0.91 | CTSK (0.44) | BCL2CTSKACEGPR132MC4R | |
| SCHEMBL4046868 | 0.90 | ITGB1 (0.37) | BCL2CTSKGPR132ITGA4ITGB7 | |
| SCHEMBL4045571 | 0.89 | CTSK (0.46) | CTSKELANE | |
| SCHEMBL4047615 | 0.89 | CTSB (0.38) | BCL2CTSKACEGPR132TAAR1 | |
| SCHEMBL4043596 | 0.89 | ELANE (0.38) | CTSKELANEGPR132MC4RMC3R | |
| SCHEMBL4047478 | 0.88 | MC4R (0.37) | CTSKACEMC4RMC3RMC1R | |
| SCHEMBL4044814 | 0.88 | FNTA (0.35) | CTSKMC4RMC3RMC1RITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |