Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 7/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047615 | 0.94 | CTSB (0.38) | F2CTSBCTSSCTSK | |
| SCHEMBL4050328 | 0.93 | SCN9A (0.39) | F2ITGA4ITGB7CTSBCTSS | |
| SCHEMBL4043952 | 0.90 | CTSK (0.42) | CTSBCTSSCTSK | |
| SCHEMBL4044160 | 0.90 | CTSB (0.37) | CTSBCTSSCTSK | |
| SCHEMBL4043998 | 0.90 | FKBP1A (0.37) | MMP8MMP13CTSBCTSSCTSK | |
| SCHEMBL4042585 | 0.89 | USP30 (0.39) | F2ITGA4ITGB7ITGB3ITGAV | |
| SCHEMBL4051785 | 0.89 | ITGA4 (0.39) | MMP8MMP13ITGA4ITGB7ITGB3 | |
| SCHEMBL4041149 | 0.87 | ITGA4 (0.39) | F2ITGA4ITGB7ITGB3ITGAV | |
| SCHEMBL4044253 | 0.85 | CTSK (0.48) | F2CTSSCTSKMAPT | |
| SCHEMBL4044857 | 0.84 | DPP4 (0.43) | MMP13KCNA5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |