Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 4/20 | 0.36 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | MC1R | Q01726 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044443 | 0.93 | ALDH1A1 (0.38) | HTRA1CTSKACACBPAX8GPR132 | |
| SCHEMBL4045179 | 0.92 | CTSK (0.44) | HTRA1CTSKC3AR1DRD4PAX8 | |
| SCHEMBL4047771 | 0.91 | CTSK (0.39) | CTSKACACBGPR132CHRNA7 | |
| SCHEMBL4046542 | 0.89 | POLB (0.36) | CTSKACACBPAX8GPR132 | |
| SCHEMBL4041238 | 0.89 | CHRNB2 (0.36) | HTRA1CTSKMC4RMC3RMC1R | |
| SCHEMBL4043616 | 0.89 | CTSK (0.35) | HTRA1CTSKPAX8TACR1GPR132 | |
| SCHEMBL4046786 | 0.88 | CHRNB2 (0.36) | HTRA1CTSKPAX8GPR132NAMPT | |
| SCHEMBL4040981 | 0.87 | CTSK (0.35) | CTSKACACBPAX8GPR132CHRNA7 | |
| SCHEMBL4045728 | 0.87 | CTSK (0.35) | CTSKC3AR1ACACBPAX8GPR132 | |
| SCHEMBL4047844 | 0.87 | SMYD3 (0.35) | HTRA1CTSKC3AR1DRD4MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |