Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050975 | 0.92 | CTSK (0.43) | CTSKPAX8ALDH1A1MMP1MMP3 | |
| SCHEMBL4038641 | 0.91 | CTSK (0.33) | CTSKPAX8PREPFAPL3MBTL1 | |
| SCHEMBL4043031 | 0.89 | HTRA1 (0.37) | CTSKPAX8HTRA1GPR132MMP1 | |
| SCHEMBL4044586 | 0.88 | CTSK (0.37) | CTSKPAX8PREPFAPGPR132 | |
| SCHEMBL4046060 | 0.87 | CTSK (0.35) | CTSKPAX8PREPFAPL3MBTL1 | |
| SCHEMBL4040719 | 0.87 | SMYD3 (0.35) | CTSKPREPFAPL3MBTL1ALDH1A1 | |
| SCHEMBL4046786 | 0.86 | CHRNB2 (0.36) | CTSKPAX8PREPFAPHTRA1 | |
| SCHEMBL4041238 | 0.86 | CHRNB2 (0.36) | CTSKPAX8PREPFAPHTRA1 | |
| SCHEMBL4047771 | 0.86 | CTSK (0.39) | CTSKGPR132 | |
| SCHEMBL4042787 | 0.86 | CHRNB2 (0.37) | CTSKPAX8PREPFAPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |