Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 6/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | MC1R | Q01726 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050866 | 0.92 | CTSK (0.43) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4045929 | 0.92 | PREP (0.36) | CTSKPREPFAPHTRA1PAX8 | |
| SCHEMBL4043031 | 0.89 | HTRA1 (0.37) | CHRNA7CTSKHTRA1PAX8MC4R | |
| SCHEMBL4046652 | 0.87 | CHRNB2 (0.35) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4043616 | 0.86 | CTSK (0.35) | CTSKPREPFAPHTRA1PAX8 | |
| SCHEMBL4047771 | 0.86 | CTSK (0.39) | CHRNA7CTSKACACBSIGMAR1 | |
| SCHEMBL4044443 | 0.85 | ALDH1A1 (0.38) | CTSKPREPFAPHTRA1PAX8 | |
| SCHEMBL4046786 | 0.85 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4CTSKPREP | |
| SCHEMBL4047976 | 0.85 | CTSK (0.43) | CTSK | |
| SCHEMBL4048207 | 0.85 | HSD17B10 (0.36) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |