Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039150 | 0.93 | CHRNA7 (0.36) | CTSKCHRNB2CHRNA7CHRNA4ALDH1A1 | |
| SCHEMBL4044616 | 0.91 | CHRNB2 (0.39) | CTSKCHRNB2CHRNA7CHRNA4MMP1 | |
| SCHEMBL4045633 | 0.89 | CTSK (0.41) | CTSKMMP1MMP3MMP9ALDH1A1 | |
| SCHEMBL4043180 | 0.89 | CHRNB2 (0.42) | CTSKCHRNB2CHRNA7CHRNA4ALDH1A1 | |
| SCHEMBL4049357 | 0.88 | CTSK (0.37) | CTSKALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL4049366 | 0.88 | CTSK (0.38) | CTSKCHRNB2CHRNA7CHRNA4AAK1 | |
| SCHEMBL4045839 | 0.85 | CTSK (0.45) | CTSK | |
| SCHEMBL4047069 | 0.85 | CTSK (0.42) | CTSKMMP1MMP3MMP9PREP | |
| SCHEMBL4051337 | 0.84 | CHRNB2 (0.43) | CTSKCHRNB2CHRNA7CHRNA4MMP1 | |
| SCHEMBL4043183 | 0.84 | CTSK (0.43) | CTSKMMP1MMP3MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |