Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050939 | 0.93 | CTSK (0.37) | BMP1SMYD3ALDH1A1POLBHTT | |
| SCHEMBL4050093 | 0.90 | HTT (0.41) | BMP1SMYD3ALDH1A1HTTRECQL | |
| SCHEMBL4047844 | 0.90 | SMYD3 (0.35) | SMYD3 | |
| SCHEMBL4043124 | 0.89 | POLB (0.34) | BMP1ALDH1A1POLBHTTRECQL | |
| SCHEMBL4043998 | 0.88 | FKBP1A (0.37) | SMYD3NAMPT | |
| SCHEMBL4048179 | 0.88 | TSHR (0.36) | BMP1ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL4046542 | 0.88 | POLB (0.36) | BMP1ALDH1A1POLBHTTRECQL | |
| SCHEMBL4047431 | 0.87 | ALDH1A1 (0.37) | SMYD3ALDH1A1KMT2ANAMPT | |
| SCHEMBL4047173 | 0.87 | SMYD3 (0.35) | SMYD3ALDH1A1TSHR | |
| SCHEMBL4045208 | 0.86 | SMYD3 (0.35) | SMYD3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |