Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046660 | 0.93 | HTT (0.40) | HTTRECQLELOVL6TSHRHSD17B10 | |
| SCHEMBL4043124 | 0.90 | POLB (0.34) | HTTRECQLTSHRLMNAALDH1A1 | |
| SCHEMBL4043650 | 0.90 | BMP1 (0.36) | HTTRECQLTSHRLMNAALDH1A1 | |
| SCHEMBL4044730 | 0.89 | LMNA (0.39) | ELOVL6TSHRHSD17B10LMNAALDH1A1 | |
| SCHEMBL4048294 | 0.89 | ALDH1A1 (0.37) | TSHRLMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4048312 | 0.88 | KCNQ1 (0.40) | ELOVL6TSHRHSD17B10LMNAALDH1A1 | |
| SCHEMBL4051941 | 0.87 | ELOVL6 (0.38) | ELOVL6TSHRLMNASMN1; SMN2 | |
| SCHEMBL4046989 | 0.87 | ALDH1A1 (0.38) | HTTELOVL6TSHRHSD17B10LMNA | |
| SCHEMBL4044048 | 0.86 | HSD17B10 (0.37) | ELOVL6TSHRHSD17B10LMNAALDH1A1 | |
| SCHEMBL4046542 | 0.85 | POLB (0.36) | HTTRECQLTSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |