Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 6/20 | 0.34 |
| ▸ | CTSK | P43235 | 10/20 | 0.34 |
| ▸ | CTSL | P07711 | 6/20 | 0.33 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | CTSV | O60911 | 2/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045633 | 0.93 | CTSK (0.41) | KDM4EALDH1A1LMNAMAPTCTSS | |
| SCHEMBL4047814 | 0.92 | CHRNB2 (0.36) | KDM4EALDH1A1LMNAMAPTCTSK | |
| SCHEMBL4041999 | 0.90 | HSD17B10 (0.36) | KDM4EALDH1A1LMNAMAPTCTSS | |
| SCHEMBL4039150 | 0.90 | CHRNA7 (0.36) | KDM4EALDH1A1LMNAMAPTCTSS | |
| SCHEMBL4046863 | 0.89 | SMYD3 (0.35) | CTSSCTSKCTSLCTSBCTSV | |
| SCHEMBL4049192 | 0.88 | CTSK (0.37) | CTSSCTSKCTSLCTSBCTSV | |
| SCHEMBL4051965 | 0.88 | MC4R (0.38) | KDM4EALDH1A1LMNAMAPTCTSK | |
| SCHEMBL4051394 | 0.88 | CTSK (0.34) | KDM4ECTSKPREPFAP | |
| SCHEMBL4042570 | 0.87 | CTSK (0.34) | ALDH1A1MAPTCTSKMC4RMC3R | |
| SCHEMBL4046502 | 0.87 | PREP (0.34) | LMNACTSSCTSKNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |