Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048376 | 0.90 | CTSK (0.51) | CTSKPIK3CDALDH1A1CTSS | |
| SCHEMBL4050761 | 0.89 | PIK3CD (0.42) | CTSKPIK3CDALDH1A1PREPFAP | |
| SCHEMBL4043459 | 0.87 | CTSK (0.41) | CTSKALDH1A1GAA | |
| SCHEMBL4040766 | 0.85 | CTSK (0.40) | CTSKALDH1A1CCR8KCNH2CTSS | |
| SCHEMBL4044247 | 0.85 | CTSK (0.39) | CTSKALDH1A1DPP8DPP9KMT2A | |
| SCHEMBL4042992 | 0.84 | CTSK (0.39) | CTSKALDH1A1GAAHSD17B10 | |
| SCHEMBL4045677 | 0.84 | HSD11B1 (0.34) | — | |
| SCHEMBL4049285 | 0.82 | CTSK (0.41) | CTSKKMT2ACTSS | |
| SCHEMBL4042279 | 0.81 | CTSK (0.37) | CTSKALDH1A1NPC1 | |
| SCHEMBL4040851 | 0.81 | PAX8 (0.37) | CTSKCYP3A4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |