Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 3/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043883 | 0.92 | CTSK (0.42) | CTSKCTSLCTSSTGM2FNTA | |
| SCHEMBL4041556 | 0.89 | CTSK (0.43) | CTSKCTSLCTSSHTRA1ITGB3 | |
| SCHEMBL4052754 | 0.89 | CTSK (0.42) | CTSKCTSLCTSSMC4RMC3R | |
| SCHEMBL4043350 | 0.89 | HTRA1 (0.35) | CTSKCTSLCTSSFNTAFNTB | |
| SCHEMBL4051296 | 0.86 | CTSL (0.39) | CTSKCTSLCTSS | |
| SCHEMBL4045333 | 0.86 | CTSK (0.53) | CTSKCTSLCTSSMEN1KMT2A | |
| SCHEMBL4045843 | 0.85 | CTSK (0.43) | CTSKCTSLCTSSTGM2MEN1 | |
| SCHEMBL4042165 | 0.85 | EPHX1 (0.37) | CTSKCTSLCTSSGPR132ACE | |
| SCHEMBL4046932 | 0.84 | GPR132 (0.35) | CTSKCTSLCTSSFNTAFNTB | |
| SCHEMBL4045091 | 0.82 | CTSK (0.61) | CTSKCTSLCTSSHPGDSMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |