Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | GPR132 | Q9UNW8 | 5/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049549 | 0.93 | GPR132 (0.38) | EPHX1CTSKACEGPR132CHRNA7 | |
| SCHEMBL6209046 | 0.90 | CTSK (0.47) | CTSKACEGPR132CMKLR2CMKLR1 | |
| SCHEMBL4040214 | 0.90 | GPR132 (0.39) | CTSKACEGPR132CHRNA7ECE1 | |
| SCHEMBL4041149 | 0.90 | ITGA4 (0.39) | CTSKACECHRNA7ECE1 | |
| SCHEMBL4045083 | 0.88 | CTSK (0.47) | EPHX1CTSKCHRNA7CTSBCTSS | |
| SCHEMBL4047771 | 0.87 | CTSK (0.39) | EPHX1CTSKGPR132CHRNA7ECE1 | |
| SCHEMBL4044160 | 0.87 | CTSB (0.37) | EPHX1CTSKACEGPR132CHRNA7 | |
| SCHEMBL4047882 | 0.86 | F2 (0.36) | EPHX1CTSKACEGPR132CHRNA7 | |
| SCHEMBL4045597 | 0.85 | ACE (0.36) | EPHX1CTSKACEGPR132CHRNA7 | |
| SCHEMBL4045030 | 0.85 | CTSK (0.41) | CTSKACEGPR132CTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |