Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 5/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 4/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044539 | 0.93 | ITGA4 (0.36) | GPR132ITGA4ITGB7CTSLCTSB | |
| SCHEMBL4051296 | 0.90 | CTSL (0.39) | CTSLCTSBCTSSCTSK | |
| SCHEMBL4044160 | 0.90 | CTSB (0.37) | GPR132CTSBCTSSCTSK | |
| SCHEMBL4049324 | 0.89 | MC4R (0.37) | ITGA4ITGB7ELANECTSKITGB3 | |
| SCHEMBL4051785 | 0.89 | ITGA4 (0.39) | ITGA4ITGB7ELANECTSKHTRA1 | |
| SCHEMBL4043350 | 0.88 | HTRA1 (0.35) | ITGA4ITGB7CTSLCTSBCTSS | |
| SCHEMBL4045311 | 0.87 | CTSK (0.43) | CTSLCTSBCTSSELANECTSK | |
| SCHEMBL4043139 | 0.86 | ELANE (0.37) | ITGA4ITGB7ELANECTSK | |
| SCHEMBL4047882 | 0.85 | F2 (0.36) | GPR132CTSBCTSSCTSKITGAV | |
| SCHEMBL4045030 | 0.84 | CTSK (0.41) | GPR132CTSLCTSSCTSKHTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |