Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 6/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | MC1R | Q01726 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4044814 | 0.93 | FNTA (0.35) | MC4RMC3RMC1RCTSKPSMB5 | |
| SCHEMBL6213366 | 0.91 | CTSK (0.42) | HTRA1MC4RMC3RMC1RCTSK | |
| SCHEMBL4051296 | 0.90 | CTSL (0.39) | CTSKCTSLCTSBCTSS | |
| SCHEMBL4045924 | 0.89 | USP30 (0.40) | HTRA1MC4RMC3RMC1RITGA4 | |
| SCHEMBL4040539 | 0.89 | MC4R (0.41) | HTRA1MC4RMC3RMC1RCTSK | |
| SCHEMBL4045030 | 0.89 | CTSK (0.41) | HTRA1MC4RMC3RMC1RCTSK | |
| SCHEMBL4045597 | 0.88 | ACE (0.36) | MC4RMC3RMC1RCTSKCTSL | |
| SCHEMBL4046932 | 0.88 | GPR132 (0.35) | HTRA1CTSKCTSLCTSBCTSS | |
| SCHEMBL4045521 | 0.87 | CTSK (0.43) | CTSKCTSLCTSBCTSS | |
| SCHEMBL4052303 | 0.86 | CTSK (0.35) | MC4RMC3RMC1RCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |