Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046147 | 0.84 | TSHR (0.44) | ALDH1A1RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL4039621 | 0.82 | CCNA2 (0.46) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4040058 | 0.81 | ALDH1A1 (0.45) | PKMALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL4039656 | 0.80 | HDAC1 (0.42) | ALDH1A1 | |
| SCHEMBL4045052 | 0.77 | LMNA (0.46) | NPSR1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL4044987 | 0.75 | MMP8 (0.51) | ALDH1A1KMT2A | |
| SCHEMBL4043128 | 0.74 | PKM (0.48) | PKMALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL4041195 | 0.73 | MMP1 (0.41) | — | |
| SCHEMBL4040963 | 0.73 | REN (0.47) | ALDH1A1KMT2AHPGD | |
| SCHEMBL3936972 | 0.73 | REN (0.47) | ALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1651592-A2 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014517-A2 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2005-02-17 | — | — | WO | disclosed |