Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042233 | 0.82 | PKM (0.48) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4040058 | 0.82 | ALDH1A1 (0.45) | NPC1RAB9ASMN1; SMN2GAAAURKB | |
| SCHEMBL4046147 | 0.79 | TSHR (0.44) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4039656 | 0.79 | HDAC1 (0.42) | GAA | |
| SCHEMBL4045052 | 0.76 | LMNA (0.46) | SMN1; SMN2ATMJAK2 | |
| SCHEMBL4044987 | 0.74 | MMP8 (0.51) | GAA | |
| SCHEMBL4043128 | 0.74 | PKM (0.48) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4041195 | 0.73 | MMP1 (0.41) | MME | |
| SCHEMBL4040963 | 0.72 | REN (0.47) | — | |
| SCHEMBL3936972 | 0.72 | REN (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651592-B1 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2009-04-29 | — | — | EP | disclosed |