Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | MC1R | Q01726 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045521 | 0.92 | CTSK (0.43) | CTSKUTS2R | |
| SCHEMBL4047535 | 0.92 | MC4R (0.38) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4044691 | 0.90 | PREP (0.35) | CTSKPREPFAPELANEMC4R | |
| SCHEMBL4041785 | 0.90 | PREP (0.35) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4043678 | 0.89 | ALDH1A1 (0.38) | CTSKPREPFAPMC4RMC3R | |
| SCHEMBL4042234 | 0.89 | ELOVL6 (0.39) | CTSK | |
| SCHEMBL4039641 | 0.89 | CTSK (0.34) | CTSKPREPFAPP2RY12 | |
| SCHEMBL4045924 | 0.89 | USP30 (0.40) | MC4RMC3RMC1R | |
| SCHEMBL4046061 | 0.89 | LMNA (0.36) | PREPFAP | |
| SCHEMBL4044814 | 0.88 | FNTA (0.35) | CTSKMC4RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |