Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 10/20 | 0.34 |
| ▸ | CTSL | P07711 | 10/20 | 0.34 |
| ▸ | CTSS | P25774 | 6/20 | 0.34 |
| ▸ | CTSB | P07858 | 4/20 | 0.34 |
| ▸ | CTSV | O60911 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040754 | 0.93 | CTSK (0.40) | CHRNB2CHRNA7CHRNA4KCNH2CTSK | |
| SCHEMBL4049254 | 0.92 | CHRNB2 (0.40) | SMYD3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4041999 | 0.90 | HSD17B10 (0.36) | SMYD3CTSKCTSLCTSSCTSB | |
| SCHEMBL6210263 | 0.90 | CTSK (0.44) | CHRNB2CHRNA7CHRNA4KCNH2CTSK | |
| SCHEMBL4043632 | 0.90 | CHRNA7 (0.40) | SMYD3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4046940 | 0.89 | KDM4E (0.35) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4048824 | 0.88 | CTSK (0.37) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4047844 | 0.88 | SMYD3 (0.35) | SMYD3CTSK | |
| SCHEMBL4046786 | 0.88 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4KCNH2CTSK | |
| SCHEMBL4051063 | 0.88 | SMYD3 (0.36) | SMYD3CTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |