Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043537 | 0.93 | PIK3CG (0.37) | CHRNB2CHRNA7CHRNA4KCNQ1MEN1 | |
| SCHEMBL4043869 | 0.93 | KCNQ1 (0.37) | CHRNB2CHRNA7CHRNA4KCNQ1TAS1R3 | |
| SCHEMBL4043843 | 0.92 | CTSK (0.41) | TAS1R3TAS1R1CTSKHSD17B10CTSL | |
| SCHEMBL4046703 | 0.91 | CHRNB2 (0.42) | CHRNB2CHRNA7CHRNA4TAS1R3TAS1R1 | |
| SCHEMBL4049366 | 0.91 | CTSK (0.38) | CHRNB2CHRNA7CHRNA4TAS1R3TAS1R1 | |
| SCHEMBL4043432 | 0.90 | KCNQ1 (0.38) | CHRNB2CHRNA7CHRNA4KCNQ1MEN1 | |
| SCHEMBL4042354 | 0.89 | TAS1R3 (0.37) | TAS1R3TAS1R1CTSKALDH1A1LMNA | |
| SCHEMBL4041991 | 0.88 | CTSK (0.46) | CTSKCTSLCTSSCTSVCTSB | |
| SCHEMBL4044616 | 0.87 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4KCNQ1KMT2A | |
| SCHEMBL4047073 | 0.86 | CHRNB2 (0.43) | CHRNB2CHRNA7CHRNA4TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |