Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.37 |
| ▸ | CTSK | P43235 | 9/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 5/20 | 0.32 |
| ▸ | CTSS | P25774 | 5/20 | 0.32 |
| ▸ | CTSV | O60911 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049248 | 0.94 | CTSV (0.31) | TAS1R3TAS1R1CTSLCTSSCTSV | |
| SCHEMBL4043383 | 0.93 | TAS1R3 (0.35) | TAS1R3TAS1R1ALDH1A1BCAT1GAA | |
| SCHEMBL4042413 | 0.91 | CTSK (0.40) | TAS1R3TAS1R1CTSKCTSLCTSS | |
| SCHEMBL4044402 | 0.90 | GAA (0.36) | TAS1R3TAS1R1ALDH1A1GAA | |
| SCHEMBL4042300 | 0.90 | CTSK (0.37) | TAS1R3TAS1R1CTSKHDAC8CTSL | |
| SCHEMBL4047148 | 0.89 | CHRNB2 (0.39) | TAS1R3TAS1R1CTSKCTSLCTSS | |
| SCHEMBL4050961 | 0.87 | CTSK (0.36) | CTSKALDH1A1RAB9A | |
| SCHEMBL4041991 | 0.86 | CTSK (0.46) | CTSKCTSLCTSSCTSVCTSB | |
| SCHEMBL4039525 | 0.86 | CTSK (0.42) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL4043929 | 0.84 | CTSV (0.32) | TAS1R3TAS1R1CTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008076427-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |