Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 9/20 | 0.32 |
| ▸ | CTSL | P07711 | 9/20 | 0.32 |
| ▸ | CTSS | P25774 | 5/20 | 0.32 |
| ▸ | CTSB | P07858 | 3/20 | 0.32 |
| ▸ | CTSV | O60911 | 2/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045921 | 0.93 | HPGD (0.38) | HPGDGAATAS1R3TAS1R1CTSK | |
| SCHEMBL4045043 | 0.93 | HPGD (0.38) | HPGDGAAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4048824 | 0.93 | CTSK (0.37) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4042533 | 0.91 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4051635 | 0.90 | HPGD (0.37) | HPGDGAAKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4046525 | 0.89 | TAS1R3 (0.34) | HPGDTAS1R3TAS1R1KDM4EALDH1A1 | |
| SCHEMBL4049254 | 0.89 | CHRNB2 (0.40) | HPGDTAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL4045167 | 0.88 | ALDH1A1 (0.38) | HPGDGAAKDM4EALDH1A1PREP | |
| SCHEMBL4045026 | 0.87 | CTSK (0.36) | GAAKDM4EALDH1A1L3MBTL1F2 | |
| SCHEMBL4046175 | 0.86 | CTSK (0.37) | HPGDGAATAS1R3TAS1R1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |