Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 8/20 | 0.35 |
| ▸ | CTSS | P25774 | 6/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042787 | 0.93 | CHRNB2 (0.37) | CTSKCHRNB2CHRNA7CHRNA4CTSS | |
| SCHEMBL4045035 | 0.93 | CTSK (0.45) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4050975 | 0.86 | CTSK (0.43) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL4038998 | 0.85 | CTSK (0.44) | CTSKCHRNA7CTSLCTSSCTSB | |
| SCHEMBL4045748 | 0.85 | CTSK (0.51) | CTSKCTSLCTSSCTSBALDH1A1 | |
| SCHEMBL4046924 | 0.85 | CTSK (0.40) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4043145 | 0.85 | CTSK (0.49) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4044586 | 0.85 | CTSK (0.37) | CTSKCHRNB2CHRNA7CHRNA4CTSS | |
| SCHEMBL4042672 | 0.84 | CTSK (0.41) | CTSKCHRNB2CHRNA7CHRNA4CTSL | |
| SCHEMBL4045083 | 0.84 | CTSK (0.47) | CTSKCHRNA7CTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |