Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042787 | 0.93 | CHRNB2 (0.37) | CTSKCHRNB2CHRNA7CHRNA4GPR132 | |
| SCHEMBL4045035 | 0.92 | CTSK (0.45) | CTSKCHRNB2CHRNA7CHRNA4CTSS | |
| SCHEMBL4047771 | 0.89 | CTSK (0.39) | CTSKCHRNA7GPR132SIGMAR1 | |
| SCHEMBL4043616 | 0.88 | CTSK (0.35) | CTSKGPR132PAX8PREPFAP | |
| SCHEMBL4046060 | 0.87 | CTSK (0.35) | CTSKCHRNA7GPR132PAX8TNKS | |
| SCHEMBL4043393 | 0.87 | FKBP1A (0.35) | CTSKCHRNB2CHRNA7CHRNA4CTSS | |
| SCHEMBL4047976 | 0.86 | CTSK (0.43) | CTSKCTSS | |
| SCHEMBL4048981 | 0.85 | CTSK (0.43) | CTSKCHRNB2CHRNA7CHRNA4CTSS | |
| SCHEMBL4038641 | 0.85 | CTSK (0.33) | CTSKGPR132PAX8TNKSPARP1 | |
| SCHEMBL4039018 | 0.85 | HSD17B10 (0.36) | CTSKCHRNB2CHRNA7CHRNA4CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |