Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 7/20 | 0.36 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048981 | 0.93 | CTSK (0.43) | CHRNB2CHRNA7CHRNA4CTSKCTSS | |
| SCHEMBL4044586 | 0.93 | CTSK (0.37) | CHRNB2CHRNA7CHRNA4CTSKGPR132 | |
| SCHEMBL4043813 | 0.88 | CHRNB2 (0.36) | CHRNB2CHRNA7CHRNA4CTSKCTSS | |
| SCHEMBL4043616 | 0.86 | CTSK (0.35) | CTSKGPR132PREPFAPPAX8 | |
| SCHEMBL4046060 | 0.86 | CTSK (0.35) | CHRNA7CTSKGPR132PREPFAP | |
| SCHEMBL4043638 | 0.85 | ALDH1A1 (0.35) | CHRNB2CHRNA7CHRNA4CTSKPREP | |
| SCHEMBL4045035 | 0.85 | CTSK (0.45) | CHRNB2CHRNA7CHRNA4CTSKCTSS | |
| SCHEMBL4046884 | 0.84 | CTSK (0.34) | CHRNB2CHRNA7CHRNA4CTSKPREP | |
| SCHEMBL4047771 | 0.84 | CTSK (0.39) | CHRNA7CTSKGPR132ACACB | |
| SCHEMBL4038641 | 0.83 | CTSK (0.33) | CTSKGPR132PREPFAPPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |