Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 10/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CYP51A1 | Q16850 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056168 | 0.94 | ALDH1A1 (0.42) | PYGLDRD2CYP51A1STAT6ALDH1A1 | |
| SCHEMBL4053170 | 0.90 | RAB9A (0.45) | PYGLDRD2CYP51A1DRD3STAT6 | |
| SCHEMBL4055536 | 0.88 | DRD2 (0.35) | PYGLDRD2CYP51A1DRD3STAT6 | |
| SCHEMBL4057362 | 0.87 | PYGL (0.39) | PYGLDRD2CYP51A1DRD3ALOX15 | |
| SCHEMBL4051134 | 0.86 | DRD2 (0.38) | PYGLDRD2CYP51A1STAT6 | |
| SCHEMBL4341339 | 0.85 | PYGL (0.39) | PYGLDRD2CYP51A1DRD3STAT6 | |
| SCHEMBL4051527 | 0.83 | DRD3 (0.39) | PYGLDRD2CYP51A1DRD3STAT6 | |
| SCHEMBL4057673 | 0.83 | PYGL (0.39) | PYGLDRD2CYP51A1DRD3STAT6 | |
| SCHEMBL19856882 | 0.83 | ALOX15 (0.42) | PYGLDRD2CYP51A1DRD3STAT6 | |
| SCHEMBL19856883 | 0.83 | ALOX15 (0.42) | PYGLDRD2CYP51A1DRD3STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |