Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PYGL | P06737 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056168 | 0.92 | ALDH1A1 (0.42) | DRD2ALDH1A1PYGLSTAT6CYP51A1 | |
| SCHEMBL4049330 | 0.90 | PYGL (0.38) | DRD3DRD2ALDH1A1PYGLSTAT6 | |
| SCHEMBL4052196 | 0.88 | DRD4 (0.38) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL4051134 | 0.84 | DRD2 (0.38) | DRD2HTR2CPYGLMEN1KMT2A | |
| SCHEMBL4055536 | 0.84 | DRD2 (0.35) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL19856959 | 0.82 | ALOX15 (0.40) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL19856908 | 0.82 | ALOX15 (0.40) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL4057673 | 0.81 | PYGL (0.39) | DRD3DRD2PYGLSTAT6CYP51A1 | |
| SCHEMBL4057362 | 0.79 | PYGL (0.39) | DRD3DRD2PYGLCYP51A1 | |
| SCHEMBL1550411 | 0.79 | ALOX15 (0.48) | DRD2PYGLSTAT6CYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |