Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.32 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.32 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.32 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057362 | 0.83 | PYGL (0.39) | DRD2CYP51A1BCAT1PYGL | |
| SCHEMBL4057673 | 0.83 | PYGL (0.39) | DRD2CYP51A1STAT6BCAT1PYGL | |
| SCHEMBL4049377 | 0.81 | CYP51A1 (0.39) | DRD2CYP51A1STAT6PYGL | |
| SCHEMBL4050835 | 0.81 | DRD2 (0.39) | DRD2CYP51A1STAT6PYGL | |
| SCHEMBL4052196 | 0.81 | DRD4 (0.38) | DRD2CYP51A1STAT6PYGL | |
| SCHEMBL4050168 | 0.81 | DRD2 (0.36) | DRD2ALDH1A1CYP51A1STAT6PYGL | |
| SCHEMBL19856906 | 0.79 | DRD2 (0.45) | DRD2ALDH1A1CYP51A1STAT6PYGL | |
| SCHEMBL4051117 | 0.78 | ALOX15 (0.42) | CYP51A1BCAT1PYGL | |
| SCHEMBL1550540 | 0.76 | DRD2 (0.40) | DRD2CYP51A1HTRA1STAT6HSPA5 | |
| SCHEMBL7983935 | 0.76 | DRD2 (0.35) | DRD2ALDH1A1CYP51A1BCAT1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |