Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 4/20 | 0.37 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057673 | 0.92 | PYGL (0.39) | DRD3DRD2PYGLCYP51A1ALOX15 | |
| SCHEMBL4057362 | 0.90 | PYGL (0.39) | DRD3DRD2PYGLCYP51A1ALOX15 | |
| SCHEMBL4053170 | 0.88 | RAB9A (0.45) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL4051117 | 0.86 | ALOX15 (0.42) | PYGLCYP51A1ALOX15 | |
| SCHEMBL4050835 | 0.84 | DRD2 (0.39) | DRD2PYGLCYP51A1TAS1R3TAS1R1 | |
| SCHEMBL4050168 | 0.84 | DRD2 (0.36) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL19856959 | 0.83 | ALOX15 (0.40) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL19856908 | 0.83 | ALOX15 (0.40) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL8004708 | 0.83 | PYGL (0.39) | DRD4DRD3DRD2DRD1DRD5 | |
| SCHEMBL4052843 | 0.83 | PYGL (0.41) | PYGLCYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |