Water

Water

SCHEMBL4060844

NCc1ccc(S(=O)(=O)O)cc1.O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 5/20 0.61
CA2 P00918 5/20 0.61
CA9 Q16790 5/20 0.61
CA12 O43570 4/20 0.61
CA4 P22748 4/20 0.61
CA6 P23280 3/20 0.61
CA5A P35218 3/20 0.61
CA7 P43166 3/20 0.61
CA14 Q9ULX7 3/20 0.61
CA5B Q9Y2D0 3/20 0.61
MAPT P10636 1/20 0.59
PSIP1 O75475 1/20 0.57
SMN1; SMN2 Q16637 2/20 0.55
KDM4E B2RXH2 1/20 0.55
TSHR P16473 3/20 0.54
ALDH1A1 P00352 2/20 0.54
NT5E P21589 1/20 0.54
LMNA P02545 1/20 0.50
ABAT P80404 1/20 0.46
HRH3 Q9Y5N1 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1754798 0.98 CA1 (0.64) CA1CA2CA9CA12CA4
Hydrochloric Acid SCHEMBL27280069 0.95 CA1 (0.65) CA1CA2CA9CA12CA4
SCHEMBL4101357 0.95 CA1 (0.61) CA1CA2CA9CA12CA4
SCHEMBL28486121 0.88 PSIP1 (0.55) CA1CA2CA9CA12CA4
Taurine SCHEMBL9729788 0.86 LMNA (0.52) CA1CA2CA9CA12CA4
SCHEMBL17923474 0.85 TSHR (0.64) CA1CA2CA9CA12CA4
Benzylamine SCHEMBL27648243 0.85 CA1 (0.54) CA1CA2CA9CA12CA4
Benzylamine SCHEMBL10860423 0.83 TSHR (0.67) CA1CA2CA9CA12CA4
SCHEMBL1806678 0.80 CA2 (0.67) CA1CA2CA9CA12CA4
Mafenide SCHEMBL1072130 0.80 CA2 (0.87) CA1CA2CA9CA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2091322-B1 CLUMP RECOGNITION ANIMAL LITTER CHURCH & DWIGHT CO INC (US) 2019-08-14 EP disclosed
EP-1853229-B1 COMPOSITION FOR ADJUSTING WATER QUALITY FOR ADMINISTRATION OF WATER SANITIZER SENSITIVE MEDICAMENTS OR VACCINES SALMIX IND E COM LTDA (BR) 2015-03-25 EP disclosed
EP-2091322-A2 CLUMP RECOGNITION ANIMAL LITTER Church & Dwight Co., Inc. (US) 2009-08-26 EP disclosed
CN-101395184-A Method for breaking down cellulose in solution BASF AG (DE) 2009-03-25 CN disclosed
WO-2008064201-A2 CLUMP RECOGNITION ANIMAL LITTER CHURCH & DWIGHT CO., INC. (US) 2008-05-29 WO disclosed
EP-1853229-A2 COMPOSITION FOR ADJUSTING WATER QUALITY FOR ADMINISTRATION OF WATER SANITIZER SENSITIVE MEDICAMENTS OR VACCINES Salmix Industria e Comercio LTDA (BR) 2007-11-14 EP disclosed
CN-1285637-C Water-thinnable polymer precursors, their preparation and use SURFACE SPECIALTIES SA (BE) 2006-11-22 CN disclosed
WO-2006087358-A2 COMPOSITION FOR ADJUSTING WATER QUALITY FOR ADMINISTRATION OF WATER SANITIZER SENSITIVE MEDICAMENTS OR VACCINES INTERVET INTERNATIONAL B.V. (NL) 2006-08-24 WO disclosed
CN-1252146-C Phosphorus-containing material, its preparation and use UCB SA (BE) 2006-04-19 CN disclosed
CN-1671765-A Water-thinnable polymer precursors, their preparation and use SURFACE SPECIALTIES SA (BE) 2005-09-21 CN disclosed
CN-1498240-A Phosphorus containing material, their preparation method and use UCB 2004-05-19 CN disclosed
CN-1094937-C Farnesyltransferase inhibiting quinazolinones JANSSEN PHARMACEUTICA NV (BE) 2002-11-27 CN disclosed
CN-1252800-A Quinazolinones with farnesyl transferase inhibiting activity JANSSEN PHARMACEUTICA NV (BE) 2000-05-10 CN disclosed
US-5885550-A CONTAINS BLUEING AGENT VALLIER DEANDRA K (US) 1999-03-23 US disclosed
US-5800601-A Food grade jet inks VIDEOJET SYSTEMS INTERNATIONAL, INC. (US) 1998-09-01 US disclosed
US-4183959-A Emollient-containing urea-based bath bead composition and the production thereof DESOTO, INC. (US) 1980-01-15 US disclosed