Sugi Predict

Sugi Predict / Compounds / SCHEMBL4063269

SCHEMBL4063269

SCHEMBL4063269

N#Cc1cc2[nH]c(C(=O)O)cc2s1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DAO P14920 5/20 0.49
▸ KDM4E B2RXH2 4/20 0.39
▸ HSD17B10 Q99714 4/20 0.39
▸ HPGD P15428 3/20 0.39
▸ GPR35 Q9HC97 2/20 0.39
▸ MAPT P10636 1/20 0.39
▸ SRD5A2 P31213 1/20 0.39
▸ NFKB1 P19838 2/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ BLM P54132 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ SMAD3 P84022 1/20 0.37
▸ ALDH1A1 P00352 4/20 0.36
▸ LMNA P02545 3/20 0.36
▸ GRIN1 Q05586 2/20 0.36
▸ CYP2C19 P33261 2/20 0.36
▸ F7 P08709 1/20 0.36
▸ F3 P13726 1/20 0.36
▸ PIN1 Q13526 1/20 0.36
▸ MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1244150 0.74 DAO (0.53) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL1243913 0.74 DAO (0.53) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL1244120 0.74 HRH4 (0.56) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL1244709 0.74 DAO (0.53) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL4055623 0.73 DAO (0.47) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL6623887 0.71 DAO (0.50) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL23293694 0.70 DAO (0.49) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL6053037 0.70 DAO (0.49) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL14345039 0.69 DAO (0.47) DAOKDM4EHSD17B10HPGDGPR35
SCHEMBL69502 0.69 DAO (0.51) DAOKDM4EHSD17B10HPGDGPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1088824-B1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PFIZER PROD INC (US) 2004-01-07 — — EP claimed
US-20030195361-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PFIZER INC. 2003-10-16 — — US claimed
US-20020183369-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors DU BOIS DAISY JOE (US) 2002-12-05 — — US claimed
US-6399601-B1 ANTIDIABETIC AGENTS; NERVOUS SYSTEM DISORDERS; ANTICHOLESTEROL AGENTS PFIZER INC. 2002-06-04 — — US claimed
EP-1088824-A2 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-04-04 — — EP claimed
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-11 — — US disclosed
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2024-07-11 — — US disclosed
EP-4149945-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2023-03-22 — — EP disclosed
CN-115551864-A Substituted tricyclic amides, analogs thereof, and methods of using the same 爱彼特生物制药公司 2022-12-30 — — CN disclosed
WO-2021229302-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2021-11-18 — — WO disclosed
US-20150050371-A1 Extract Formulations of Rhodamnia Cinerea And Uses Thereof BIOTROPICS MALAYSIA BERHAD (MY) 2015-02-19 — — US disclosed
WO-2013133685-A1 EXTRACT FORMULATIONS OF RHODAMNIA CINEREA AND USES THEREOF BIOTROPICS MALAYSIA BERHAD (MY) 2013-09-12 — — WO disclosed
US-20020006946-A1 Tetrazole compounds as thyroid receptor ligands PFIZER INC. 2002-01-17 — — US disclosed
US-20010046958-A1 Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors TREADWAY JUDITH L (US) 2001-11-29 — — US disclosed
US-20010046956-A1 Methods of treating obesity using a neurotensin receptor ligand HADCOCK JOHN R (US) 2001-11-29 — — US disclosed
EP-1157695-A1 Method of treating obesity using a neurotensin receptor ligand Pfizer Products Inc. (US) 2001-11-28 — — EP disclosed
EP-1136071-A2 Use of glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-09-26 — — EP disclosed
EP-1127882-A1 Tetrazole compounds as thyroid receptor ligands Pfizer Products Inc. (US) 2001-08-29 — — EP disclosed
EP-1125580-A2 Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-08-22 — — EP disclosed
EP-1088824-A2 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors Pfizer Products Inc. (US) 2001-04-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195361-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PYGL, GYS1, PYGM DAO 1915/4885KDM4E 3388/4885HSD17B10 212/4885
US-20240228504-A1 SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME SLC10A1, NR1H4, SLC10A2 DAO 69/4885KDM4E 1496/4885HSD17B10 237/4885
US-20010046958-A1 Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors PYGM, GYS1, PYGL DAO 1094/4885KDM4E 1287/4885HSD17B10 732/4885
US-20020006946-A1 Tetrazole compounds as thyroid receptor ligands TSHR, THRA, THRB DAO 1344/4885KDM4E 3587/4885HSD17B10 862/4885
US-20020183369-A1 Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors PYGL, PYGM, PYGB DAO 1906/4885KDM4E 2517/4885HSD17B10 154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.