Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.62 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983179 | 0.96 | ADRB2 (0.66) | ADRB2ADRB1ADRB3LPAR1HDAC3 | |
| SCHEMBL11293636 | 0.90 | LPAR1 (0.70) | ADRB2ADRB1ADRB3LPAR1MAPT | |
| SCHEMBL29028798 | 0.90 | LPAR1 (0.70) | ADRB2ADRB1ADRB3LPAR1MAPT | |
| SCHEMBL9463643 | 0.88 | LPAR1 (0.71) | ADRB2ADRB1ADRB3LPAR1HDAC3 | |
| Phenylbutanoic Acid SCHEMBL28794522 | 0.88 | HDAC3 (0.61) | ADRB2ADRB1ADRB3LPAR1HDAC3 | |
| Phenylbutanoic Acid SCHEMBL15285203 | 0.85 | HDAC1 (0.75) | HDAC3MAPK1ADRA1AHDAC4SLC6A3 | |
| SCHEMBL11855276 | 0.82 | ADRB2 (0.52) | ADRB2ADRB1ADRB3LPAR1KDM4E | |
| SCHEMBL27457920 | 0.82 | KDM4E (0.64) | LPAR1MAPTKDM4EDUSP3MEN1 | |
| SCHEMBL270754 | 0.82 | LMNA (0.69) | LPAR1MAPTKDM4EDUSP3MEN1 | |
| SCHEMBL8427652 | 0.81 | ADRB2 (0.55) | ADRB2ADRB1ADRB3LPAR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11786494-B2 | Methods of modulation of branched chain acids and uses thereof | BAYLOR COLLEGE OF MEDICINE (US) | 2023-10-17 | — | — | US | claimed |
| US-20200405678-A1 | METHODS OF TREATING UREA CYCLE DISORDERS | HORIZON THERAPEUTICS, LLC | 2020-12-31 | — | — | US | claimed |
| EP-3222275-B1 | METHODS OF THERAPEUTIC MONITORING OF PHENYLACETIC ACID PRODRUGS | IMMEDICA PHARMA AB (SE) | 2020-06-24 | — | — | EP | claimed |
| US-20200147016-A1 | METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF | ACER THERAPEUTICS INC. | 2020-05-14 | — | — | US | claimed |
| US-10617665-B2 | Methods of therapeutic monitoring of nitrogen scavenging drugs | HORIZON THERAPEUTICS, LLC (US) | 2020-04-14 | — | — | US | claimed |
| EP-2986325-B1 | METHODS OF TREATING UREA CYCLE DISORDERS | IMMEDICA PHARMA AB (SE) | 2019-06-26 | — | — | EP | claimed |
| US-20190151268-A1 | METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF | ACER THERAPEUTICS INC. | 2019-05-23 | — | — | US | claimed |
| US-20190125713-A1 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | HORIZON THERAPEUTICS U.S. HOLDING LLC | 2019-05-02 | — | — | US | claimed |
| US-10183002-B2 | Methods of therapeutic monitoring of nitrogen scavenging drugs | HORIZON THERAPEUTICS, LLC (US) | 2019-01-22 | — | — | US | claimed |
| US-10183006-B2 | Methods of therapeutic monitoring of nitrogen scavenging drugs | HORIZON THERAPEUTICS, LLC (US) | 2019-01-22 | — | — | US | claimed |
| EP-2760479-A2 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | Hyperion Therapeutics, Inc. (US) | 2014-08-06 | — | — | EP | claimed |
| WO-2014081977-A1 | METHODS OF ADMINISTERING AND EVALUATING NITROGEN SCAVENGING DRUGS FOR THE TREATMENT OF HEPATIC ENCEPHALOPATHY | SCHARSCHMIDT BRUCE (US) | 2014-05-30 | — | — | WO | claimed |
| US-20140142186-A1 | METHODS OF ADMINISTERING AND EVALUATING NITROGEN SCAVENGING DRUGS FOR THE TREATMENT OF HEPATIC ENCEPHALOPATHY | HORIZON THERAPEUTICS U.S. HOLDING LLC | 2014-05-22 | — | — | US | claimed |
| US-8642012-B2 | Methods of treatment using ammonia-scavenging drugs | HYPERION THERAPEUTICS, INC. (US) | 2014-02-04 | — | — | US | claimed |
| US-20130210914-A1 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | HYPERION THERAPEUTICS, INC. (US) | 2013-08-15 | — | — | US | claimed |
| WO-2013079205-A1 | LOW DOSE THERAPEUTIC USE OF GLYCERYL TRI-(4-PHENYLBUTYRATE) | LUNAMED AG (CH) | 2013-06-06 | — | — | WO | claimed |
| EP-2599482-A1 | Low dose therapeutic use of glyceryl tri-(4-phenylbutyrate) | Lunamed AG (CH) | 2013-06-05 | — | — | EP | claimed |
| US-20130085179-A1 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | HORIZON THERAPEUTICS U.S. HOLDING LLC | 2013-04-04 | — | — | US | claimed |
| WO-2013048558-A2 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | HYPERION THERAPEUTICS, INC. (US) | 2013-04-04 | — | — | WO | claimed |
| US-8404215-B1 | Methods of therapeutic monitoring of nitrogen scavenging | HYPERION THERAPEUTICS, INC. (US) | 2013-03-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151268-A1 | METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF | OAT, ABAT, BCKDK | ADRB2 2725/4885ADRB1 1772/4885ADRB3 1121/4885 |
| US-20200405678-A1 | METHODS OF TREATING UREA CYCLE DISORDERS | UROD, SLC14A1, UGDH | ADRB2 3988/4885ADRB1 3660/4885ADRB3 3991/4885 |
| US-20130085179-A1 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | OAT, NPR1, CPS1 | ADRB2 1778/4885ADRB1 1837/4885ADRB3 1956/4885 |
| US-20190125713-A1 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | OAT, NPR1, CPS1 | ADRB2 1778/4885ADRB1 1837/4885ADRB3 1956/4885 |
| US-10617665-B2 | Methods of therapeutic monitoring of nitrogen scavenging drugs | OAT, NPR1, CPS1 | ADRB2 1778/4885ADRB1 1837/4885ADRB3 1956/4885 |
| US-10183002-B2 | Methods of therapeutic monitoring of nitrogen scavenging drugs | OAT, NPR1, CPS1 | ADRB2 1778/4885ADRB1 1837/4885ADRB3 1956/4885 |
| US-10183006-B2 | Methods of therapeutic monitoring of nitrogen scavenging drugs | OAT, NPR1, CPS1 | ADRB2 1778/4885ADRB1 1837/4885ADRB3 1956/4885 |
| US-20130210914-A1 | METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS | OAT, NPR1, CPS1 | ADRB2 1778/4885ADRB1 1837/4885ADRB3 1956/4885 |
| US-20200147016-A1 | METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF | OAT, ABAT, BCKDK | ADRB2 2725/4885ADRB1 1772/4885ADRB3 1121/4885 |
| US-11786494-B2 | Methods of modulation of branched chain acids and uses thereof | OAT, ABAT, BCKDK | ADRB2 2725/4885ADRB1 1772/4885ADRB3 1121/4885 |
| US-20140142186-A1 | METHODS OF ADMINISTERING AND EVALUATING NITROGEN SCAVENGING DRUGS FOR THE TREATMENT OF HEPATIC ENCEPHALOPATHY | OAT, OTC, GLS2 | ADRB2 2022/4885ADRB1 2184/4885ADRB3 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.