Acyclovir

Acyclovir

SCHEMBL40722

Nc1nc([O-])c2ncn(COCCO)c2n1.[Na+]

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acyclovir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EDNRA known ✓ P25101 1/20 0.58
PNP P00491 7/20 0.58
HBB P68871 2/20 0.58
BLM P54132 2/20 0.58
USP2 O75604 1/20 0.58
TSHR P16473 1/20 0.58
HTR2A P28223 1/20 0.58
RECQL P46063 1/20 0.58
HSD17B10 Q99714 1/20 0.58
HPRT1 P00492 3/20 0.45
POLG P54098 1/20 0.41
CDK1 P06493 2/20 0.40
CCNB1 P14635 2/20 0.40
CCNE1 P24864 2/20 0.40
CDK2 P24941 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPK1 P28482 1/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acyclovir SCHEMBL4604274 0.99 PNP (0.57) PNPHBBBLMUSP2TSHR
SCHEMBL571583 0.85 PNP (0.62) PNPHBBBLMUSP2TSHR
Hydrochloric Acid SCHEMBL11250267 0.84 PNP (0.61) PNPHBBBLMUSP2TSHR
Acyclovir SCHEMBL9828560 0.84 PNP (0.61) PNPHBBBLMUSP2TSHR
SCHEMBL11724984 0.83 PNP (0.60) PNPHBBBLMUSP2TSHR
SCHEMBL10585595 0.83 PNP (0.60) PNPHBBBLMUSP2TSHR
Ganciclovir SCHEMBL15567856 0.82 BLM (0.71) PNPHBBBLMUSP2TSHR
Ganciclovir SCHEMBL149822 0.81 BLM (0.58) PNPHBBBLMUSP2TSHR
Ganciclovir SCHEMBL29588756 0.81 BLM (0.58) PNPHBBBLMUSP2TSHR
SCHEMBL9233727 0.81 PNP (0.57) PNPHBBBLMUSP2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2023 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026043843-A1 TETRAHYDROPYRIMIDINE (THP) IONIZABLE LIPIDS FOR EFFICIENT MRNA DELIVERY THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (US) 2026-02-26 WO claimed
WO-2024215771-A1 SUBSTITUTED PHENYL ETHYNYL PYRIMIDINES AS POTENT INHIBITORS OF ALPHAVIRUSES SOUTHERN RESEARCH INSTITUTE (US) 2024-10-17 WO claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
CN-117860743-A Application of sirolimus in preparation of specific binding agent of coronavirus spike protein receptor binding domain 五邑大学 2024-04-12 CN claimed
CN-115919823-B Application of benserazide hydrochloride in preparing medicament for treating diseases caused by respiratory syncytial virus 浙江艾特为生物科技有限公司 2024-04-05 CN claimed
CN-117677631-A Novel compositions and methods for treating coronavirus infections 昆士兰医学研究所理事会 2024-03-08 CN claimed
EP-4326757-A1 NOVEL COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTIONS The Council of the Queensland Institute of Medical Research (AU) 2024-02-28 EP claimed
EP-4262812-A1 6-AZA-NUCLEOSIDE PRODRUGS AS ANTIVIRAL AGENTS FOR TREATING VIRUS INFECTIONS Southern Research Institute (US) 2023-10-25 EP claimed
WO-2023122212-A2 SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS SOUTHERN RESEARCH INSTITUTE (US) 2023-06-29 WO claimed
CN-115916175-A Novel 2-pyrimidinone analogs as potent antiviral agents against alphaviruses 南方研究院 2023-04-04 CN claimed
WO-2000024386-A1 METHOD OF MAKING PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES CONTAINING HYDROPHILIC SALTS OF DRUGS THERATECH, INC. (US) 2000-05-04 WO claimed
WO-1999063970-A1 DELAVIRDINE TABLET FORMULATION PHARMACIA & UPJOHN COMPANY (US) 1999-12-16 WO claimed
US-5985317-A POLYISOBUTYLENE; BACKING IMPERMEABLE TO DICLOFENAC SODIUM THERATECH, INC. (US) 1999-11-16 US claimed
EP-0952799-A1 PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES FOR TRANSDERMAL DELIVERY OF SALTS OF PHARMACEUTICAL AGENTS THERATECH, INC. (US) 1999-11-03 EP claimed
WO-1998031370-A1 READY-TO-USE SOLUTION DRUG PRODUCT AND CLOSURE SYSTEM MERIDIAN MEDICAL TECHNOLOGIES, INC. (US) 1998-07-23 WO claimed
WO-1998009591-A1 PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES FOR TRANSDERMAL DELIVERY OF SALTS OF PHARMACEUTICAL AGENTS THERATECH, INC. (US) 1998-03-12 WO claimed
US-5357636-A Flexible protective medical gloves and methods for their use DRESDNER JR KARL P (US) 1994-10-25 US claimed
EP-0544878-A1 ASIALOGLYCOPROTEIN-CONJUGATED MEDICINAL AGENT COREA GREEN CROSS CORPORATION (KR) 1993-06-09 EP claimed
CN-1068744-A The medicament of Asialoglycoprotein-conjugated medicinal LIVER RESEARCH FOUNDATION OF K (KR) 1993-02-10 CN claimed
WO-1992022310-A1 ASIALOGLYCOPROTEIN-CONJUGATED MEDICINAL AGENT LIVER RESEARCH FOUNDATION OF KOREA (KR) 1992-12-23 WO claimed