SCHEMBL407449

SCHEMBL407449

N#Cc1ccc(O)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
AR P10275 3/20 0.49
CYP19A1 P11511 7/20 0.47
CA2 P00918 2/20 0.46
CA1 P00915 1/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
CA6 P23280 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
VCAM1 P19320 1/20 0.44
TMPRSS4 Q9NRS4 1/20 0.42
ESR2 Q92731 1/20 0.42
MMP3 P08254 1/20 0.41
FLT1 P17948 1/20 0.40
FLT4 P35916 1/20 0.40
KDR P35968 1/20 0.40
P2RX1 P51575 1/20 0.40
PDK1 Q15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
O-Xylene SCHEMBL27630964 0.87 AR (0.56) TSHRHSD17B10ARCYP19A1CA2
Propionic Acid SCHEMBL10760281 0.84 CA2 (0.47) ARCYP19A1CA2TMPRSS4PDK1
SCHEMBL7222655 0.84 ESR2 (0.60) TSHRHSD17B10ARCYP19A1CA2
SCHEMBL3759580 0.82 TSHR (0.50) TSHRHSD17B10ARCYP19A1CA2
SCHEMBL31053017 0.82 TSHR (0.50) TSHRHSD17B10ARCYP19A1CA2
SCHEMBL11143323 0.81 PTGS1 (0.57) TSHRHSD17B10ARCYP19A1CA2
SCHEMBL11143320 0.81 PTGS1 (0.57) TSHRHSD17B10ARCYP19A1CA2
SCHEMBL4257041 0.79 BACE1 (0.49) ARCYP19A1CA2CA12CA3
SCHEMBL4257044 0.79 BACE1 (0.49) ARCYP19A1CA2CA12CA3
SCHEMBL825866 0.78 VCAM1 (0.53) TSHRHSD17B10ARCA2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 329 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0375069-B1 Benzamide compounds, their preparation and their use as pesticides SHELL INT RESEARCH (NL) 1994-03-09 EP claimed
US-5155135-A Insecticides, miticides SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ, B.V. (NL) 1992-10-13 US claimed
EP-0375069-A1 Benzamide compounds, their preparation and their use as pesticides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-06-27 EP claimed
EP-0093976-B1 2,4-DIHALOGENBENZOYL UREAS AND THIOUREAS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES BAYER AG (DE) 1986-09-10 EP claimed
JP-62153954-A None JP disclosed
JP-58074776-A None JP disclosed
US-12617762-B2 Carboxy derivatives with antiinflamatory properties SITRYX THERAPEUTICS LIMITED (GB) 2026-05-05 US disclosed
EP-4081511-B3 CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES SITRYX THERAPEUTICS LTD (GB) 2026-03-04 EP disclosed
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-20250214942-A1 INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-07-03 US disclosed
US-20250176544-A1 A process for the Preparation Nitrile Herbicides, their Esters and Salts GHARDA CHEMICALS LIMITED (IN) 2025-06-05 US disclosed
CN-120040369-A Oxadiazole amide c-Myc inhibitor and preparation method and application thereof 上海深势唯思科技有限责任公司 2025-05-27 CN disclosed
EP-0080371-B1 DIPHENOXYPROPANE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1985-02-20 EP disclosed
EP-0080371-A1 Diphenoxypropane derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1983-06-01 EP disclosed
US-4385006-A Process for preparing aromatic nitriles 501 SOCIETE FRANCAISE HOECHST (FR) 1983-05-24 US disclosed
JP-S5874776-A NEMATIC LIQUID CRYSTAL MIXTURE SEIKO EPSON CORP 1983-05-06 JP disclosed
US-4360672-A Substituted phenoxyphenyl pyridazones, their preparation, and their use as herbicides BASF AKTIENGESELLSCHAFT (DE) 1982-11-23 US disclosed
US-4027018-A INSECTICIDES, ACARACIDES, NEMATOCIDES BAYER AKTIENGESELLSCHAFT (DT) 1977-05-31 US disclosed
US-4000270-A INSECTIDES, ACARICIDES, NEMATOCIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-12-28 US disclosed
US-3954919-A INSECTICIDES, MITICIDES, NEMATOCIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214942-A1 INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE RIPK1, RIPK2, RIPK4 TSHR 2948/4885HSD17B10 3233/4885AR 3435/4885
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL TSHR 1083/4885HSD17B10 35/4885AR 2967/4885
US-12617762-B2 Carboxy derivatives with antiinflamatory properties CCR1, CBR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 TSHR 3443/4885HSD17B10 1051/4885AR 3195/4885
US-20250176544-A1 A process for the Preparation Nitrile Herbicides, their Esters and Salts DDT, ALK, PPP4C TSHR 2757/4885HSD17B10 441/4885AR 3137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.