Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083518 | 0.89 | LMNA (0.44) | MCHR1HRH3KDM4EHDAC1MAPT | |
| SCHEMBL4093445 | 0.88 | LMNA (0.44) | MCHR1HRH3KDM4EHDAC1MAPT | |
| SCHEMBL4086291 | 0.87 | MAPK1 (0.44) | MCHR1HRH3KDM4EHDAC1MAPT | |
| SCHEMBL4083509 | 0.86 | GPR35 (0.49) | KDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4083876 | 0.84 | KIT (0.45) | FLT3KDR | |
| SCHEMBL4088619 | 0.84 | GPR35 (0.42) | MAPTALDH1A1THRB | |
| SCHEMBL4083134 | 0.84 | GPR35 (0.42) | KDM4EHDAC1MAPTALDH1A1 | |
| SCHEMBL4088637 | 0.83 | ALDH1A1 (0.43) | KDM4EMAPTALDH1A1TSHR | |
| SCHEMBL4083005 | 0.83 | MAPT (0.44) | MAPTFLT3HDAC8KDRTSHR | |
| SCHEMBL4088668 | 0.83 | SMN1; SMN2 (0.54) | MAPTL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |