Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083509 | 0.90 | GPR35 (0.49) | GPR35MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL4091779 | 0.89 | LMNA (0.44) | GPR35MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL4088619 | 0.88 | GPR35 (0.42) | GPR35MAPTPPARGPPARAALDH1A1 | |
| SCHEMBL4088637 | 0.88 | ALDH1A1 (0.43) | GPR35MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL4078418 | 0.87 | HTT (0.43) | MAPTALDH1A1HPGDKDM4EGAA | |
| SCHEMBL4078733 | 0.85 | ALDH1A1 (0.44) | GPR35MAPTALDH1A1KDM4EELANE | |
| SCHEMBL4082122 | 0.84 | MCHR1 (0.42) | MAPTALDH1A1KDM4EHDAC1 | |
| SCHEMBL4078227 | 0.83 | PAX8 (0.45) | GPR35MAPTALDH1A1KDM4EGAA | |
| SCHEMBL4084033 | 0.83 | ELANE (0.45) | GPR35ALDH1A1ELANENPC1 | |
| SCHEMBL4083252 | 0.83 | PTK2 (0.37) | GPR35MAPTALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |