Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | STK33 | Q9BYT3 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082088 | 0.92 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2NPC1KDM4EMAPK1 | |
| SCHEMBL13850061 | 0.85 | AURKA (0.46) | RAB9ASMN1; SMN2NPC1KDM4ENFKB1 | |
| SCHEMBL4083272 | 0.85 | APLNR (0.47) | RAB9ASMN1; SMN2NPC1KDM4EMAPK1 | |
| SCHEMBL4083197 | 0.84 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2NPC1MAPK1STK33 | |
| SCHEMBL4088416 | 0.83 | LMNA (0.42) | RAB9ASMN1; SMN2NPC1KDM4EMAPK1 | |
| SCHEMBL4084047 | 0.81 | AURKA (0.42) | HTT | |
| SCHEMBL651489 | 0.80 | RXFP1 (0.47) | RAB9ASMN1; SMN2NPC1KDM4EMAPK1 | |
| SCHEMBL4083484 | 0.78 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2NPC1KDM4ENFKB1 | |
| SCHEMBL4091695 | 0.78 | MAPK1 (0.45) | RAB9ASMN1; SMN2NPC1KDM4EMAPK1 | |
| SCHEMBL653335 | 0.78 | FADS1 (0.36) | RAB9ASMN1; SMN2NPC1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |