Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1426816 | 0.98 | KMT2A (0.46) | KMT2AMEN1KDM4EHPGDCYP3A4 | |
| Bromide SCHEMBL1457139 | 0.97 | KMT2A (0.45) | KMT2AMEN1KDM4EHPGDCYP3A4 | |
| Sulfuric Acid SCHEMBL3399748 | 0.88 | KMT2A (0.40) | KMT2AMEN1KDM4EHPGDCYP3A4 | |
| Hydrochloric Acid SCHEMBL4605053 | 0.75 | HSD17B10 (0.46) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL1426641 | 0.72 | HSD17B10 (0.47) | KMT2AMEN1KDM4EALDH1A1GAA | |
| SCHEMBL3118165 | 0.70 | MAPT (0.50) | KMT2AMEN1KDM4EHPGDALDH1A1 | |
| SCHEMBL3110299 | 0.69 | ALDH1A1 (0.51) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14128779 | 0.68 | CYP3A4 (0.56) | KMT2AMEN1KDM4EHPGDCYP3A4 | |
| SCHEMBL5315601 | 0.67 | KMT2A (0.36) | KMT2AMEN1KDM4EHPGDCYP3A4 | |
| SCHEMBL839103 | 0.66 | ALOX15 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944010-B1 | Brightening and/or colouring agent with acrylic acid derivative(s) | HENKEL AG & CO KGAA (DE) | 2015-03-11 | — | — | EP | disclosed |
| EP-2081543-A2 | BLEACHING AGENT COMPRISING PIPERIDONE/S AND IMIDAZOLE/S | Henkel AG & Co. KGaA (DE) | 2009-07-29 | — | — | EP | disclosed |
| EP-1972323-A2 | Hair colorant | Henkel AG & Co. KGaA (DE) | 2008-09-24 | — | — | EP | disclosed |
| WO-2008095558-A2 | BLEACHING AGENT COMPRISING PIPERIDONE/S AND IMIDAZOLE/S | HENKEL AG & CO. KGAA (DE) | 2008-08-14 | — | — | WO | disclosed |
| EP-1944010-A2 | Brightening and/or colouring agent with acrylic acid derivative(s) | Henkel AG & Co. KGaA (DE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1909913-A1 | METHOD FOR QUICKLY CONCEALING THE ROOTS OF HAIR THAT HAVE GROWN AFTER THE HAIR HAS BEEN DYED | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-04-16 | — | — | EP | disclosed |
| EP-1776984-A2 | Method for extending the recoloring cycles | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-04-25 | — | — | EP | disclosed |
| WO-2007017048-A1 | METHOD FOR QUICKLY CONCEALING THE ROOTS OF HAIR THAT HAVE GROWN AFTER THE HAIR HAS BEEN DYED | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2007-02-15 | — | — | WO | disclosed |