SCHEMBL409810

SCHEMBL409810

COc1cc(C(=O)NC2CCN(P(=O)(OCC(C)(C)C)C(C)(C)C)CC2)cc(OC)c1OC

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.50
MEN1 O00255 1/20 0.48
PKM P14618 1/20 0.48
KMT2A Q03164 1/20 0.48
MAPK1 P28482 1/20 0.47
OPRK1 P41145 1/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPK10 P53779 1/20 0.47
TSHR P16473 1/20 0.47
POLB P06746 1/20 0.46
MMP2 P08253 3/20 0.44
ANPEP P15144 2/20 0.44
CXCR6 O00574 2/20 0.44
CXCR4 P61073 1/20 0.43
SSTR5 P35346 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23347841 0.87 MCHR1 (0.49) MCHR1MEN1PKMKMT2AMAPK1
SCHEMBL409841 0.83 USP2 (0.42) MCHR1ALDH1A1MAPK10TSHRPOLB
SCHEMBL408769 0.82 KMT2A (0.51) MCHR1MEN1KMT2AALDH1A1POLB
SCHEMBL12065590 0.81 MAPK1 (0.56) MCHR1MEN1PKMKMT2AMAPK1
SCHEMBL463419 0.80 MAPK1 (0.57) MCHR1MEN1PKMKMT2AMAPK1
SCHEMBL408142 0.79 ALDH1A1 (0.51) MCHR1MEN1KMT2AALDH1A1TSHR
SCHEMBL15443874 0.79 MCHR1 (0.53) MCHR1MEN1PKMKMT2AMAPK1
SCHEMBL409337 0.78 MAPK1 (0.48) MCHR1MEN1KMT2AMAPK1ALDH1A1
SCHEMBL408161 0.78 MCHR1 (0.46) MCHR1MEN1KMT2AALDH1A1TSHR
SCHEMBL408989 0.78 USP30 (0.54) MCHR1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11732259-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
US-11732259-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
US-20210139897-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS SAREPTA THERAPEUTICS, INC. 2021-05-13 US disclosed
US-20210139896-A1 Peptide Oligonucleotide Conjugates JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2021-05-13 US disclosed
US-10760078-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2020-09-01 US disclosed
US-10398721-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2019-09-03 US disclosed
US-20190218551-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2019-07-18 US disclosed
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2018-04-05 US disclosed
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2018-04-05 US disclosed
US-9862946-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2018-01-09 US disclosed
US-9326992-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2016-05-03 US disclosed
US-20160102307-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2016-04-14 US disclosed
US-9161948-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2015-10-20 US disclosed
US-9066967-B2 Oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2015-06-30 US disclosed
US-20150073140-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS SAREPTA THERAPEUTICS, INC. (US) 2015-03-12 US disclosed
US-8779128-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2014-07-15 US disclosed
US-20140024821-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. (US) 2014-01-23 US disclosed
US-20140024698-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. (US) 2014-01-23 US disclosed
US-20120289457-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES AVI BIOPHARMA, INC. (US) 2012-11-15 US disclosed
US-20120065169-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2012-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190218551-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB MCHR1 4395/4885MEN1 3261/4885PKM 3658/4885
US-20120065169-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB MCHR1 4395/4885MEN1 3261/4885PKM 3658/4885
US-10398721-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA LMNA, LMNB2, LMNB1 MCHR1 4237/4885MEN1 1171/4885PKM 2552/4885
US-20160102307-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNB2, LMNA, LMNB1 MCHR1 3586/4885MEN1 817/4885PKM 3828/4885
US-10760078-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups NSUN2, UPF1, RTCB MCHR1 4395/4885MEN1 3261/4885PKM 3658/4885
US-20210139896-A1 Peptide Oligonucleotide Conjugates SNRPE, SMN1; SMN2, UPF1 MCHR1 2815/4885MEN1 1532/4885PKM 3267/4885
US-20150073140-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB MCHR1 4395/4885MEN1 3261/4885PKM 3658/4885
US-20140024698-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNA, LMNB2, LMNB1 MCHR1 4237/4885MEN1 1171/4885PKM 2552/4885
US-20210139897-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB MCHR1 4395/4885MEN1 3261/4885PKM 3658/4885
US-20120289457-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES SNRPE, SMN1; SMN2, UPF1 MCHR1 2815/4885MEN1 1532/4885PKM 3267/4885
US-11732259-B2 Peptide oligonucleotide conjugates SNRPE, SMN1; SMN2, UPF1 MCHR1 2815/4885MEN1 1532/4885PKM 3267/4885
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNB2, LMNA, LMNB1 MCHR1 3586/4885MEN1 817/4885PKM 3828/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.