SCHEMBL410063

SCHEMBL410063

CS(=O)(=O)c1cccc(C#N)c1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MCOLN3 Q8TDD5 1/20 0.51
PPME1 Q9Y570 1/20 0.47
PGR P06401 1/20 0.47
RXFP1 Q9HBX9 1/20 0.46
PTGS2 P35354 2/20 0.46
ENPP2 Q13822 1/20 0.46
ACLY P53396 2/20 0.45
NR1H3 Q13133 1/20 0.45
KAT6A Q92794 1/20 0.44
CTSG P08311 1/20 0.44
CMA1 P23946 1/20 0.44
GLO1 Q04760 1/20 0.44
SLC40A1 Q9NP59 1/20 0.44
TRIM24 O15164 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30915555 1.00 MCOLN3 (0.51) MCOLN3PPME1PGRRXFP1PTGS2
Hydrochloric Acid SCHEMBL29739267 0.98 MCOLN3 (0.50) MCOLN3PPME1PGRRXFP1PTGS2
SCHEMBL3510232 0.85 PGR (0.52) PGRNR1H3
SCHEMBL5441030 0.82 PTGS2 (0.47) PTGS2
SCHEMBL1891657 0.82 MCOLN3 (0.49) MCOLN3PPME1PGRRXFP1ENPP2
SCHEMBL13911254 0.81 PSIP1 (0.50) MCOLN3PPME1PGRRXFP1ENPP2
SCHEMBL689244 0.80 ADAMTS4 (0.55) MCOLN3PGRPTGS2ACLYKAT6A
SCHEMBL1487652 0.80 TSHR (0.52) MCOLN3PPME1PGRRXFP1ENPP2
SCHEMBL791765 0.80 CA2 (0.67) MCOLN3PGR
SCHEMBL4574069 0.80 KAT6A (0.48) MCOLN3PGRRXFP1ENPP2ACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 232 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118054087-A Electrolyte, electrolyte injection method and lithium metal battery 蜂巢能源科技股份有限公司 2024-05-17 CN claimed
CN-113130994-A Electrolyte and electrochemical device comprising same 深圳市研一新材料有限责任公司 2021-07-16 CN claimed
US-9870909-B2 Compositions and methods for mass spectometry MSTM, LLC 2018-01-16 US claimed
US-12570645-B2 Uses of p53 x-ray co-crystal structures PMV PHARMACEUTICALS, INC. (US) 2026-03-10 US disclosed
US-20260027097-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION PMV PHARMACEUTICALS INC (US) 2026-01-29 US disclosed
US-20250319063-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION PMV PHARMACEUTICALS, INC. 2025-10-16 US disclosed
US-12419880-B2 Companion diagnostic tool for mutant p53 reactivating compounds PMV PHARMACEUTICALS, INC. (US) 2025-09-23 US disclosed
US-20240269126-A1 COMBINATION THERAPY FOR TREATMENT OF CANCER PMV PHARMACEUTICALS, INC. 2024-08-15 US disclosed
CN-118054087-B Electrolyte, electrolyte injection method and lithium metal battery 蜂巢能源科技股份有限公司 2024-07-19 CN disclosed
CN-118054087-A Electrolyte, electrolyte injection method and lithium metal battery 蜂巢能源科技股份有限公司 2024-05-17 CN disclosed
US-11938124-B2 Combination therapy for treatment of cancer PMV PHARMACEUTICALS, INC. (US) 2024-03-26 US disclosed
US-20030162808-A1 Acetindine derivatives, their preparation and medicaments containing them AVENTIS PHARMA S.A. (FR) 2003-08-28 US disclosed
EP-1112251-B1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA SA (FR) 2003-05-07 EP disclosed
US-6518264-B2 For treatment/prevention of psychoses, other brain disorders, and cardiovascular disorders AVENTIS PHARMA S.A. (FR) 2003-02-11 US disclosed
US-20020035102-A1 Azetidine derivatives, their preparation and medicaments containing them AVENTIS PHARMA S.A. (FR) 2002-03-21 US disclosed
EP-1112251-A1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM Aventis Pharma S.A. (FR) 2001-07-04 EP disclosed
WO-2000015609-A1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA S.A. (FR) 2000-03-23 WO disclosed
EP-0003259-B1 N-FORMYLANILIDO AROMATIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PROCESS FOR THE PREPARATION OF THE CORRESPONDING N-PHENYL AROMATIC AMINO COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-03-24 EP disclosed
EP-0003259-A1 N-Formylanilido aromatic compounds, process for their preparation and process for the preparation of the corresponding N-phenyl aromatic amino compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1979-08-08 EP disclosed
US-4103009-A ANTIULCER AGENTS, DIURETICS NIPPON SHINYAKU CO., LTD. (JP) 1978-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11938124-B2 Combination therapy for treatment of cancer TP53, KRAS, TP53BP1 MCOLN3 4518/4885PPME1 203/4885PGR 2359/4885
US-20250319063-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION TP53, TP53BP1, KRAS MCOLN3 4551/4885PPME1 102/4885PGR 2544/4885
US-20260027097-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION TP53, TP53BP1, BRCA1 MCOLN3 3413/4885PPME1 353/4885PGR 2158/4885
US-12570645-B2 Uses of p53 x-ray co-crystal structures TP53, TP53BP1, ERCC2 MCOLN3 4316/4885PPME1 270/4885PGR 869/4885
US-20240269126-A1 COMBINATION THERAPY FOR TREATMENT OF CANCER TP53, KRAS, TP53BP1 MCOLN3 4518/4885PPME1 203/4885PGR 2359/4885
US-12419880-B2 Companion diagnostic tool for mutant p53 reactivating compounds TP53, TP53BP1, KRAS MCOLN3 4607/4885PPME1 764/4885PGR 1501/4885
US-20020035102-A1 Azetidine derivatives, their preparation and medicaments containing them CYP11B2, AZI2, CYP2C19 MCOLN3 2339/4885PPME1 3442/4885PGR 449/4885
US-20030162808-A1 Acetindine derivatives, their preparation and medicaments containing them ADRA1D, ADRB2, AZI2 MCOLN3 3297/4885PPME1 4103/4885PGR 2283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.