Sugi Predict

Sugi Predict / Compounds / SCHEMBL4101513

SCHEMBL4101513

SCHEMBL4101513

NC(=O)c1ccccc1C[CH]c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.47
▸ MAPT P10636 4/20 0.47
▸ ALDH1A1 P00352 3/20 0.47
▸ HPGD P15428 3/20 0.47
▸ LMNA P02545 1/20 0.47
▸ SIRT2 Q8IXJ6 1/20 0.43
▸ BCAT2 O15382 1/20 0.43
▸ TSHR P16473 2/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ METAP2 P50579 1/20 0.40
▸ SIRT1 Q96EB6 2/20 0.40
▸ ADRA1D P25100 1/20 0.40
▸ CTNNB1 P35222 1/20 0.40
▸ PARP1 P09874 2/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ AKR1C3 P42330 1/20 0.38
▸ POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3159978 0.86 SIRT1 (0.46) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL28624746 0.83 PTGER4 (0.56) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL630666 0.79 KDM4E (0.47) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL8930563 0.79 KDM4E (0.47) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL4981766 0.79 KDM4E (0.42) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL630127 0.78 KDM4E (0.45) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL6336723 0.78 KDM4E (0.45) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL83923 0.78 KDM4E (0.50) KDM4EMAPTALDH1A1HPGDLMNA
SCHEMBL4651184 0.78 BCAT2 (0.41) BCAT2PARP1
SCHEMBL3727463 0.77 ADRA1D (0.45) KDM4EMAPTALDH1A1HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030195212-A1 Novel melanocortin receptor agonists and antagonists MELACURE THERAPEUTICS AB (SE) 2003-10-16 — — US claimed
US-20090123563-A1 Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand NOVO NORDISK A/S (DK) 2009-05-14 — — US disclosed
EP-1585541-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING INSULIN AND LEGENDS OF INSULIN HEXAMER NOVO NORDISK AS (DK) 2007-11-14 — — EP disclosed
EP-1429763-B1 NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER NOVO NORDISK AS (DK) 2007-05-30 — — EP disclosed
EP-1768694-A1 PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN NOVO NORDISK A/S (DK) 2007-04-04 — — EP disclosed
US-20060258561-A1 Novel NPH insulin preparations NOVO NORDISK A/S (DK) 2006-11-16 — — US disclosed
WO-2006082245-A1 PHARMACEUTICAL PREPARATIONS COMPRISING INSULIN, ZINC IONS AND A ZINC-BINDING LIGAND NOVO NORDISK A/S (DK) 2006-08-10 — — WO disclosed
US-20060069013-A1 Pharmaceutical preparations comprising acid-stabilised insulin NOVO NORDISK A/S (DK) 2006-03-30 — — US disclosed
WO-2006005683-A1 PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN NOVO NORDISK A/S (DK) 2006-01-19 — — WO disclosed
EP-1610812-A1 PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN NOVO NORDISK A/S (DK) 2006-01-04 — — EP disclosed
WO-2004080481-A1 NOVEL NPH INSULIN PREPARATIONS NOVO NORDISK A/S (DK) 2004-09-23 — — WO disclosed
WO-2004080480-A1 PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN NOVO NORDISK A/S (DK) 2004-09-23 — — WO disclosed
WO-2004056347-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING INSULIN AND LEGENDS OF INSULIN HEXAMER NOVO NORDISK A/S (DK) 2004-07-08 — — WO disclosed
EP-1429763-A2 NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER NOVO NORDISK A/S (DK) 2004-06-23 — — EP disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 — — WO disclosed
US-20030229120-A1 Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer NOVO NORDISK A/S (DK) 2003-12-11 — — US disclosed
WO-2003027081-A2 NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER NOVO NORDISK A/S (DK) 2003-04-03 — — WO disclosed
EP-1254114-A2 MELANOCORTIN RECEPTOR AGONISTS AND ANTAGONISTS Melacure Therapeutics AB (SE) 2002-11-06 — — EP disclosed
WO-2001055106-A2 NOVEL MELANOCORTIN RECEPTOR AGONISTS AND ANTAGONISTS MELACURE THERAPEUTICS AB (SE) 2001-08-02 — — WO disclosed
US-4822786-A Cephalosporin compounds, and antibacterial agents KAKEN PHARMACEUTICAL CO., LTD. (JP) 1989-04-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195212-A1 Novel melanocortin receptor agonists and antagonists MC1R, MC5R, MC4R KDM4E 1977/4885MAPT 1226/4885ALDH1A1 2823/4885
US-20060258561-A1 Novel NPH insulin preparations IAPP, HBB, INSR KDM4E 4791/4885MAPT 1772/4885ALDH1A1 4866/4885
US-20060069013-A1 Pharmaceutical preparations comprising acid-stabilised insulin IAPP, GPR119, INSR KDM4E 4773/4885MAPT 2757/4885ALDH1A1 4795/4885
US-20030229120-A1 Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer IAPP, IRS1, GPR119 KDM4E 4783/4885MAPT 4207/4885ALDH1A1 4873/4885
US-20090123563-A1 Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand IAPP, IRS1, HBB KDM4E 4599/4885MAPT 1785/4885ALDH1A1 4836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.