SCHEMBL411514

SCHEMBL411514

N#Cc1ccc(-c2cc(C(=O)O)cnc2OCC(F)(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.47
MAP4K4 O95819 1/20 0.47
CNR1 P21554 3/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
PTGS2 P35354 2/20 0.46
SLC22A12 Q96S37 1/20 0.45
CTSA P10619 1/20 0.44
RORA P35398 2/20 0.43
RORC P51449 2/20 0.43
EGLN1 Q9GZT9 1/20 0.41
GSK3A P49840 1/20 0.41
GSK3B P49841 1/20 0.41
MRGPRX4 Q96LA9 1/20 0.40
EGLN2 Q96KS0 1/20 0.39
HCRTR1 O43613 1/20 0.39
HCRTR2 O43614 1/20 0.39
VNN1 O95497 2/20 0.39
PTPN11 Q06124 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14761796 0.88 CNR1 (0.47) PTGDR2MAP4K4CNR1PTGS2CTSA
SCHEMBL15670295 0.85 L3MBTL1 (0.52) PTGDR2MAP4K4CNR1L3MBTL1PTGS2
SCHEMBL440662 0.84 CNR1 (0.62) PTGDR2MAP4K4CNR1L3MBTL1PTGS2
SCHEMBL410534 0.82 PTGS2 (0.49) CNR1L3MBTL1PTGS2SLC22A12RORA
SCHEMBL16554363 0.82 CTSA (0.57) MAP4K4CNR1SLC22A12CTSAEGLN2
SCHEMBL412338 0.81 CNR1 (0.48) CNR1L3MBTL1PTGS2SLC22A12CTSA
SCHEMBL2127732 0.80 CNR1 (0.50) CNR1L3MBTL1PTGS2SLC22A12MRGPRX4
SCHEMBL14762013 0.80 CNR1 (0.49) CNR1PTGS2CTSARORARORC
SCHEMBL29173889 0.79 MAP4K4 (0.47) PTGDR2MAP4K4CNR1SLC22A12CTSA
SCHEMBL14761485 0.79 CNR1 (0.52) CNR1CTSAEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4537901-A2 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS F. Hoffmann-La Roche AG (CH) 2025-04-16 EP disclosed
EP-3826679-B1 ABCA1-INDUCING COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS HOFFMANN LA ROCHE (CH) 2024-11-27 EP disclosed
US-20240325372-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS HOFFMANN LA ROCHE (US) 2024-10-03 US disclosed
CN-112469442-B Compounds for treating kidney disorders 豪夫迈·罗氏有限公司 2024-04-09 CN disclosed
CN-117736141-A Compounds for treating kidney disorders 豪夫迈·罗氏有限公司 2024-03-22 CN disclosed
US-20210275514-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS HOFFMANN LA ROCHE (US) 2021-09-09 US disclosed
EP-3826679-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS F. Hoffmann-La Roche AG (CH) 2021-06-02 EP disclosed
CN-112469442-A Compounds for treating kidney disorders 豪夫迈·罗氏有限公司 2021-03-09 CN disclosed
US-20200085810-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS HOFFMANN-LA ROCHE INC. 2020-03-19 US disclosed
WO-2020021097-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2020-01-30 WO disclosed
WO-2013037703-A1 3 -PYRIDINE CARBOXYLIC ACID HYDRAZIDES AS HDL-CHOLESTEROL RAISING AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-21 WO disclosed
WO-2013037703-A1 3 -PYRIDINE CARBOXYLIC ACID HYDRAZIDES AS HDL-CHOLESTEROL RAISING AGENTS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-21 WO disclosed
US-20130065876-A1 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES F. HOFFMANN-LA ROCHE AG (CH) 2013-03-14 US disclosed
US-20130065876-A1 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES F. HOFFMANN-LA ROCHE AG (CH) 2013-03-14 US disclosed
US-20130065876-A1 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES F. HOFFMANN-LA ROCHE AG (CH) 2013-03-14 US disclosed
US-20120065212-A1 HETEROARYLMETHYL AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 US disclosed
US-20120065212-A1 HETEROARYLMETHYL AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 US disclosed
US-20120065212-A1 HETEROARYLMETHYL AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 US disclosed
WO-2012032018-A1 HETEROARYLMETHYL AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 WO disclosed
WO-2012032018-A1 HETEROARYLMETHYL AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130065876-A1 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES HMGCR, HCAR3, HCAR1 PTGDR2 2530/4885MAP4K4 2567/4885CNR1 303/4885
US-20210275514-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS GLS, ATP6V1B1, PLAAT2 PTGDR2 492/4885MAP4K4 2515/4885CNR1 1563/4885
US-20240325372-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS GLS, ATP6V1B1, DGKB PTGDR2 766/4885MAP4K4 2902/4885CNR1 2972/4885
US-20200085810-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS GLS, ATP6V1B1, PLAAT2 PTGDR2 492/4885MAP4K4 2515/4885CNR1 1563/4885
US-20120065212-A1 HETEROARYLMETHYL AMIDES APOB, LDLR, HMGCR PTGDR2 2386/4885MAP4K4 4374/4885CNR1 269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.