SCHEMBL4126147

SCHEMBL4126147

O=C(O)CNC(=O)COc1cccc2c1Cc1ccccc1-2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TSHR P16473 1/20 0.45
NPSR1 Q6W5P4 2/20 0.43
RAB9A P51151 4/20 0.42
NPC1 O15118 2/20 0.42
PTGIR P43119 1/20 0.42
HTT P42858 3/20 0.41
PLA2G1B P04054 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
ATG4B Q9Y4P1 1/20 0.41
CD69 Q07108 1/20 0.41
ALDH1A1 P00352 4/20 0.41
LMNA P02545 2/20 0.41
HSD17B10 Q99714 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
MAPT P10636 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HPGD P15428 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10736267 0.88 CD69 (0.53) RAB9ANPC1PTGIRL3MBTL1CD69
SCHEMBL22804037 0.82 RAB9A (0.44) MEN1KMT2ANPSR1RAB9ANPC1
SCHEMBL28607402 0.79 LMNA (0.53) RAB9ANPC1CD69LMNA
SCHEMBL8410783 0.77 LMNA (0.64) MEN1KMT2ANPSR1RAB9ANPC1
SCHEMBL14037316 0.75 DRD2 (0.57) TSHRRAB9ANPC1
SCHEMBL9206495 0.74 PNMT (0.43) KMT2ARAB9ANPC1HTTALDH1A1
SCHEMBL30898587 0.74 PNMT (0.43) KMT2ARAB9ANPC1HTTALDH1A1
SCHEMBL14638181 0.73 ALDH1A1 (0.74) MEN1KMT2ATSHRALDH1A1LMNA
SCHEMBL29430517 0.72 PNMT (0.47) KMT2ARAB9ANPC1HTTCD69
SCHEMBL3459355 0.72 PNMT (0.47) KMT2ARAB9ANPC1HTTCD69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004099288-A1 POLYETHYLENEIMINE POLYMERS CARLSBERG A/S (DK) 2004-11-18 WO claimed
US-20090023606-A1 Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof VERSAMATRIX A/S (DK) 2009-01-22 US disclosed
EP-1778740-A1 BEADED AND CROSS-LINKED POLY(AMINOALKYLENE) MATRIX AND USES THEREOF VersaMatrix A/S (DK) 2007-05-02 EP disclosed
WO-2006015594-A1 BEADED AND CROSS-LINKED POLY(AMINOALKYLENE) MATRIX AND USES THEREOF VERSAMATRIX A/S (DK) 2006-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023606-A1 Beaded and Cross-Linked Poly(Aminoalkylene)Matrix and Uses Thereof PLOD3, PLOD2, PCNA MEN1 4833/4885KMT2A 344/4885TSHR 4814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.